牙周病中叶酸受体 1 水平：一项初步研究。
Folate-receptor 1 level in periodontal disease: a pilot study.
机构信息
Department of Periodontology, Faculty of Dentistry, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Department of Biochemistry, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
出版信息
BMC Oral Health. 2019 Oct 11;19(1):218. doi: 10.1186/s12903-019-0909-z.
BACKGROUND
The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status.
METHODS
The study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent assay.
RESULTS
The values of FOLR1 in GCF were higher in gingivitis and periodontitis groups than among patient in control group (p < 0.016). Serum FOLR1 levels showed no significant difference between the groups. A significant correlation was observed between FOLR1 levels of GCF and BOP (p < 0.05).
CONCLUSIONS
Our preliminary data suggest that FOLR1 is not useful in monitoring the periodontal disease. Further studies are necessary to clarify the role, regulation and function of folate and it's receptors in the pathogenesis of periodontal disease.
背景
本研究旨在探讨不同牙周状况患者龈沟液（GCF）和血清叶酸受体 1（FOLR1）水平。
方法
本研究包括三组：健康组（n=15）、牙龈炎组（n=15）和慢性牙周炎组（n=15）。评估临床牙周参数，包括探诊袋深度（PPD）、临床附着水平（CAL）、牙龈指数（GI）和探诊出血（BOP）。从每位患者中采集龈沟液和血清样本，并通过酶联免疫吸附试验分析 FOLR1 水平。
结果
GCF 中的 FOLR1 值在牙龈炎和牙周炎组中高于对照组（p<0.016）。各组血清 FOLR1 水平无显著差异。GCF 中 FOLR1 水平与 BOP 呈显著相关性（p<0.05）。
结论
我们的初步数据表明，FOLR1 不能用于监测牙周病。需要进一步研究阐明叶酸及其受体在牙周病发病机制中的作用、调节和功能。
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