Stine R A, Magorien R D, Bush C A, Kolibash A J, Leier C V, Fertel R H, Brandt J, Unverferth D V
Cathet Cardiovasc Diagn. 1985;11(3):247-54. doi: 10.1002/ccd.1810110304.
Platelet function and prostaglandin activity were evaluated in nine patients with coronary artery disease undergoing percutaneous left anterior descending coronary artery angioplasty (PTCA) and compared to nine normal controls. Transcoronary measurements (arterial-coronary sinus) of platelet counts, mean platelet volume, platelet factor 4 (PF4), beta thromboglobulin, thromboxane (B2), and 6-keto-PGF 1 alpha were made. When compared to normal controls, the patients with coronary artery disease had higher circulating baseline levels of PF4 in the coronary sinus. There was no transcardiac production of any factor at baseline or immediately after infusion of nitroglycerin or performance of PTCA. These results suggest that PTCA does not grossly alter arachidonic acid metabolism or platelet activity.
对9例接受经皮左前降支冠状动脉血管成形术（PTCA）的冠心病患者的血小板功能和前列腺素活性进行了评估，并与9名正常对照者进行比较。进行了经冠状动脉测量（动脉-冠状窦），以测定血小板计数、平均血小板体积、血小板因子4（PF4）、β-血小板球蛋白、血栓素（B2）和6-酮-前列环素F1α。与正常对照者相比，冠心病患者冠状窦中PF4的循环基线水平较高。在基线时、输注硝酸甘油后或进行PTCA后立即，未发现任何因子的经心产生。这些结果表明，PTCA不会显著改变花生四烯酸代谢或血小板活性。
