多中心低级别胶质瘤的综合生存分析。
An Integrative Survival Analysis for Multicentric Low-Grade Glioma.
机构信息
Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Neurosurgery, Xi'an Central Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, China.
出版信息
World Neurosurg. 2020 Feb;134:e189-e195. doi: 10.1016/j.wneu.2019.10.001. Epub 2019 Oct 9.
OBJECTIVE
This study aimed to perform a survival analysis of patients with multicentric low-grade gliomas (MLGGs) and to assess the influence of various prognostic factors on progression-free survival (PFS) and overall survival.
METHODS
A literature search on Web of Science and PubMed was performed for literature in English published from 1963 to September 2018. Detailed information including demographics, clinical characteristics, treatments, critical events, and time to events for survival analysis were extracted from the included articles.
RESULTS
A total of 36 cases from published articles were selected for analysis. Univariate analysis showed that age (<31 years or ≥31 years), grade (pure low grade/low and high grade) and glioma type (astrocytoma/oligodendroglioma) had a significant relationship with PFS. Cox regression analysis showed that tumor grade was an independent prognostic factor for PFS. No factors correlated with overall survival.
CONCLUSIONS
This integrative analysis of MLGGs patients revealed that age younger than 31 years, pure MLGG, and oligodendroglioma were significantly associated with improved PFS, and pure MLGGs was an independent prognostic factors for PFS.
目的
本研究旨在对多中心低级别胶质瘤（MLGGs）患者进行生存分析，并评估各种预后因素对无进展生存期（PFS）和总生存期的影响。
方法
对 Web of Science 和 PubMed 数据库进行了英文文献检索，检索时间截至 2018 年 9 月。从纳入的文献中提取了详细的信息，包括人口统计学、临床特征、治疗、关键事件和生存分析的时间。
结果
共选择了 36 篇已发表文章中的病例进行分析。单因素分析显示，年龄（<31 岁或≥31 岁）、分级（纯低级别/低级别和高级别）和胶质瘤类型（星形细胞瘤/少突胶质细胞瘤）与 PFS 有显著关系。Cox 回归分析显示，肿瘤分级是 PFS 的独立预后因素。没有与总生存期相关的因素。
结论
对 MLGGs 患者的综合分析表明，年龄<31 岁、纯 MLGG 和少突胶质细胞瘤与 PFS 显著相关，纯 MLGG 是 PFS 的独立预后因素。
Zotero 插件