Naranjo J R, Fernandez-Roman M, Urdin M C, Fuentes J A
Gen Pharmacol. 1985;16(3):287-90. doi: 10.1016/0306-3623(85)90086-2.
The hypotensive action of two novel imidazolinic alpha-adrenergic agonists (ICI-106270 and UK-14304) with similar pharmacological properties to clonidine was shown in spontaneously hypertensive (SH) rats. The antihypertensive effect of the clonidine-type agents was prevented by either peripheral administration of the opiate antagonist naloxone or by intracerebroventricular (i.c.v.) injection with a specific antibody against human beta-endorphin (BEN). A dose-response relationship was found for the hypotensive effect of i.c.v. given BEN in SH rats, the low blood pressure being significantly reversed by further treatment with either naloxone or anti-beta h-endorphin. These data confirm and extend the notion of a BEN mediation in the antihypertensive action of clonidine-type alpha-adrenergic agonists in SH rats.
两种新型咪唑啉类α-肾上腺素能激动剂（ICI-106270和UK-14304），其药理特性与可乐定相似，在自发性高血压（SH）大鼠中显示出降压作用。可乐定类药物的降压作用可通过外周给予阿片拮抗剂纳洛酮或脑室内（i.c.v.）注射抗人β-内啡肽（BEN）的特异性抗体来阻断。在SH大鼠中发现了脑室内给予BEN的降压作用的剂量反应关系，进一步用纳洛酮或抗β h-内啡肽治疗可显著逆转低血压。这些数据证实并扩展了BEN介导可乐定类α-肾上腺素能激动剂在SH大鼠中降压作用的观点。
