Aix-Marseille Université, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Service d'Anesthésie et de Réanimation, Marseille, France.
University of Queensland Centre for Clinical Research, Faculty of Medicine & Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Anaesth Crit Care Pain Med. 2019 Dec;38(6):647-656. doi: 10.1016/j.accpm.2019.09.009. Epub 2019 Oct 10.
The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these issues is discussed with key messages presented after a brief review of evidence.
2019 年尼姆国际抗生素治疗优化研讨会旨在确定为重症患者管理抗生素的一些最佳策略。专家们回顾了与优化抗生素管理计划的要求、重症患者抗生素治疗剂量不足的风险、联合治疗的效率以及降级的价值、药代动力学的新观点、包括抗生素相关副作用的药物毒性、抗生素雾化的应用、接受体外治疗的患者的管理以及新型抗生素的应用等方面的最新文献。本文简要回顾了相关证据后，对每个问题进行了讨论，并提出了关键信息。
