Jeurissen S H, Schmidt E D, Sminia T, Kraal G
Int Arch Allergy Appl Immunol. 1985;77(4):384-9. doi: 10.1159/000233813.
In the present study the effects of a large oral dose of the contact allergen dinitrochlorobenzene (DNCB) on the distribution of T-cell subsets in the small intestines and the emigration pattern of lymphocytes from Peyer's patches were investigated. Apart from the inflammatory effects, DNCB administration resulted in an influx on the T-helper cells in the villi. Precise quantification of T lymphocytes showed a decrease in Peyer's patches and an increase in mesenteric lymph node cell suspensions. However, no differences could be found in the emigration rate of T-cell subsets from Peyer's patches into mesenteric lymph nodes, suggesting that the increase of T cells in mesenteric lymph nodes results from T-helper cells directly immigrating from the villi.
在本研究中，研究了大剂量口服接触性变应原二硝基氯苯（DNCB）对小肠中T细胞亚群分布以及派尔集合淋巴结淋巴细胞移出模式的影响。除炎症作用外，给予DNCB导致绒毛中辅助性T细胞流入。T淋巴细胞的精确量化显示，派尔集合淋巴结中的T淋巴细胞数量减少，肠系膜淋巴结细胞悬液中的T淋巴细胞数量增加。然而，未发现派尔集合淋巴结中T细胞亚群向肠系膜淋巴结的移出率存在差异，这表明肠系膜淋巴结中T细胞数量的增加是由辅助性T细胞直接从绒毛迁移而来的。
