Mikhael Matthew, Makar Christian, Wissa Amir, Le Trixie, Eghbali Mansoureh, Umar Soban
Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States.
Front Physiol. 2019 Sep 24;10:1233. doi: 10.3389/fphys.2019.01233. eCollection 2019.
Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by increased pulmonary artery pressures. Long standing pulmonary arterial pressure overload leads to right ventricular (RV) hypertrophy, RV failure, and death. RV failure is a major determinant of survival in PH. Oxidative stress has been associated with the development of RV failure secondary to PH. Here we summarize the structural and functional changes in the RV in response to sustained pulmonary arterial pressure overload. Furthermore, we review the pre-clinical and clinical studies highlighting the association of oxidative stress with pulmonary vasculature and RV remodeling in chronic PH. Targeting oxidative stress promises to be an effective therapeutic strategy for the treatment of RV failure.
肺动脉高压（PH）是一种以肺动脉压力升高为特征的肺血管疾病。长期的肺动脉压力过载会导致右心室（RV）肥厚、右心室衰竭和死亡。右心室衰竭是肺动脉高压患者生存的主要决定因素。氧化应激与继发于肺动脉高压的右心室衰竭的发生有关。在此，我们总结了右心室在持续肺动脉压力过载反应中的结构和功能变化。此外，我们回顾了临床前和临床研究，这些研究突出了氧化应激与慢性肺动脉高压中肺血管系统和右心室重塑之间的关联。针对氧化应激有望成为治疗右心室衰竭的有效治疗策略。
