Yan Fang, Pidayi Muyeshaer, Xia Yu, Hu Xin, Yang Zengrong
Department of Respiratory Medicine, the First Affiliated Hospital of Xinjiang Medical University, Liyushan S. RD, Urumqi, Xinjiang, PR China.
Pak J Pharm Sci. 2019 Jul;32(4):1697-1701.
Chronic Obstructive Pulmonary Disease (COPD), which is caused by various proinflammatory cytokines, will present some kinds of complication with progression such as Pulmonary Artery Hypertension (PAH). CRP (C-Reactive Protein) and ET-1(Endotheline-1) play pivotal function in inflammatory responses. The aim of this study is to investigate the prognosis value of CRP and ET-1 in COPD patients with pulmonary artery hypertension. CRP and ET-1 were measured in the plasma, sputum and exhaled breath condensate (EBC) of 55 COPD patients, 75 COPD patients with PAH and 57 healthy controls. Then, we analyzed the influence of these two proteins on the lung function, pulmonary artery pressure, exercise capacity and other clinical indices. The amount of CRP and ET-1 were the highest in COPD patients with PAH, followed by the COPD patients and the healthy controls. And there were statistically significant differences (p<0.05). The amount of CRP and ET-1 were negatively correlated with the lung function and exercise capacity, positively correlated with the pulmonary artery pressure. CRP and ET-1 are two valuable indicators in the diagnosis of COPD patients with PAH in clinic.
慢性阻塞性肺疾病（COPD）由多种促炎细胞因子引起，随着病情进展会出现诸如肺动脉高压（PAH）等多种并发症。CRP（C反应蛋白）和ET-1（内皮素-1）在炎症反应中起关键作用。本研究旨在探讨CRP和ET-1对COPD合并肺动脉高压患者的预后价值。检测了55例COPD患者、75例COPD合并PAH患者及57例健康对照者血浆、痰液和呼出气冷凝液（EBC）中的CRP和ET-1。然后，分析这两种蛋白对肺功能﹑肺动脉压力、运动能力及其他临床指标的影响。COPD合并PAH患者的CRP和ET-1含量最高，其次是COPD患者和健康对照者。差异具有统计学意义（p<0.05）。CRP和ET-1含量与肺功能和运动能力呈负相关，与肺动脉压力呈正相关。CRP和ET-1是临床上诊断COPD合并PAH患者的两个有价值的指标。
