精准医学案例：女性中风和心血管风险评估的个性化方法。
Cases in Precision Medicine: A Personalized Approach to Stroke and Cardiovascular Risk Assessment in Women.
机构信息
Columbia University Irving Medical Center, New York, New York (N.A.B., E.C.M., K.L.C., R.W.).
出版信息
Ann Intern Med. 2019 Dec 3;171(11):837-842. doi: 10.7326/M19-1601. Epub 2019 Oct 15.
Abstract
Cardiovascular disease is the leading cause of death among women in the United States, and stroke is third. This article uses a case scenario to examine female sex-specific cardiovascular risk factors across the lifespan and describes a precision medicine-based approach to risk factor modification and primary prevention. It also presents recent updates to the role of genetic testing and polygenic risk scores for the prediction of stroke and cardiovascular disease.
摘要
心血管疾病是美国女性死亡的主要原因，中风是第三大死因。本文通过案例情景检查了女性在整个生命周期中特有的心血管危险因素，并描述了一种基于精准医学的危险因素改变和一级预防方法。本文还介绍了基因检测和多基因风险评分在中风和心血管疾病预测中的作用的最新更新。
相似文献
1
Cases in Precision Medicine: A Personalized Approach to Stroke and Cardiovascular Risk Assessment in Women.精准医学案例：女性中风和心血管风险评估的个性化方法。
Ann Intern Med. 2019 Dec 3;171(11):837-842. doi: 10.7326/M19-1601. Epub 2019 Oct 15.
2
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.低剂量阿司匹林用于女性心血管疾病一级预防的随机试验。
N Engl J Med. 2005 Mar 31;352(13):1293-304. doi: 10.1056/NEJMoa050613. Epub 2005 Mar 7.
3
The Long-Term Benefits of Increased Aspirin Use by At-Risk Americans Aged 50 and Older.50岁及以上美国高危人群增加阿司匹林使用量的长期益处。
PLoS One. 2016 Nov 30;11(11):e0166103. doi: 10.1371/journal.pone.0166103. eCollection 2016.
4
[Italian intersocietary consensus document on aspirin therapy in primary cardiovascular prevention].[意大利关于阿司匹林在心血管疾病一级预防中应用的跨学会共识文件]
G Ital Cardiol (Rome). 2014 Jul-Aug;15(7-8):442-51. doi: 10.1714/1596.17424.
5
Aspirin in primary prevention of cardiovascular disease in the elderly.阿司匹林在老年人心血管疾病一级预防中的应用
Eur Heart J Cardiovasc Pharmacother. 2020 Sep 1;6(5):326-327. doi: 10.1093/ehjcvp/pvz046.
6
Aspirin for the prevention of cardiovascular disease: recommendation statement.阿司匹林用于预防心血管疾病：推荐声明。
Am Fam Physician. 2011 Jun 15;83(12):1464-8.
7
Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials.阿司匹林用于糖尿病患者心血管疾病及全因死亡事件的一级预防：随机对照试验的最新荟萃分析
Diabet Med. 2017 Mar;34(3):316-327. doi: 10.1111/dme.13133. Epub 2016 May 22.
8
Aspirin for Primary and Secondary Prevention of Cardiovascular Disease.阿司匹林用于心血管疾病的一级和二级预防
Tex Heart Inst J. 2016 Aug 1;43(4):318-9. doi: 10.14503/THIJ-16-5807. eCollection 2016 Aug.
9
Application of U.S. guidelines in other countries: aspirin for the primary prevention of cardiovascular events in Japan.美国指南在其他国家的应用：阿司匹林用于日本心血管事件的一级预防。
Am J Med. 2004 Oct 1;117(7):459-68. doi: 10.1016/j.amjmed.2004.04.017.
10
Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview Survey.美国阿司匹林用于心血管疾病一级预防的流行情况：2017年全国健康访谈调查结果
Ann Intern Med. 2019 Oct 15;171(8):596-598. doi: 10.7326/M19-0953. Epub 2019 Jul 23.
本文引用的文献
1
Aspirin for Primary Prevention of Cardiovascular Events.阿司匹林用于心血管疾病一级预防
J Am Coll Cardiol. 2019 Jun 18;73(23):2915-2929. doi: 10.1016/j.jacc.2019.03.501.
2
Selective Use of Coronary Artery Calcium Testing for Shared Decision Making: Guideline Endorsed and Ready for Prime Time.冠状动脉钙化检测在共同决策中的选择性应用：指南认可且已准备好广泛应用。
Ann Intern Med. 2019 Feb 19;170(4):262-263. doi: 10.7326/M18-3675.
3
Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.《2019年心脏病和中风统计数据更新：美国心脏协会报告》
Circulation. 2019 Mar 5;139(10):e56-e528. doi: 10.1161/CIR.0000000000000659.
4
Aspirin reduces long-term stroke risk in women with prior hypertensive disorders of pregnancy.阿司匹林可降低有妊娠高血压病史的女性的长期中风风险。
Neurology. 2019 Jan 22;92(4):e305-e316. doi: 10.1212/WNL.0000000000006815. Epub 2018 Dec 26.
5
Migraine with visual aura is a risk factor for incident atrial fibrillation: A cohort study.伴有视觉先兆的偏头痛是新发心房颤动的一个危险因素：一项队列研究。
Neurology. 2018 Dec 11;91(24):e2202-e2210. doi: 10.1212/WNL.0000000000006650. Epub 2018 Nov 14.
6
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2017美国心脏病学会/美国心脏协会/美国医师助理学会/美国心脏病学学会/美国预防医学学院/美国老年病学会/美国药剂师协会/美国血液学会/美国预防心脏病学会/美国国家医学协会/美国初级保健医师学会成人高血压预防、检测、评估和管理指南：执行摘要：美国心脏病学会/美国心脏协会临床实践指南工作组报告
Circulation. 2018 Oct 23;138(17):e426-e483. doi: 10.1161/CIR.0000000000000597.
7
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.阿司匹林对健康老年人心血管事件和出血的影响。
N Engl J Med. 2018 Oct 18;379(16):1509-1518. doi: 10.1056/NEJMoa1805819. Epub 2018 Sep 16.
8
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.全基因组多基因疾病风险评分可识别出与单基因突变风险相当的个体。
Nat Genet. 2018 Sep;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z. Epub 2018 Aug 13.
9
Estrogen, migraine, and vascular risk.雌激素、偏头痛和血管风险。
Neurol Sci. 2018 Jun;39(Suppl 1):11-20. doi: 10.1007/s10072-018-3333-2.
10
Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration With Obstetricians and Gynecologists: A Presidential Advisory From the American Heart Association and the American College of Obstetricians and Gynecologists.通过与妇产科医生合作促进女性心血管疾病风险的识别与降低：美国心脏协会和美国妇产科医师学会的主席咨询意见
Circulation. 2018 Jun 12;137(24):e843-e852. doi: 10.1161/CIR.0000000000000582. Epub 2018 May 10.
Zotero 插件