Columbia University Irving Medical Center, New York, New York (N.A.B., E.C.M., K.L.C., R.W.).
Ann Intern Med. 2019 Dec 3;171(11):837-842. doi: 10.7326/M19-1601. Epub 2019 Oct 15.
Cardiovascular disease is the leading cause of death among women in the United States, and stroke is third. This article uses a case scenario to examine female sex-specific cardiovascular risk factors across the lifespan and describes a precision medicine-based approach to risk factor modification and primary prevention. It also presents recent updates to the role of genetic testing and polygenic risk scores for the prediction of stroke and cardiovascular disease.
心血管疾病是美国女性死亡的主要原因，中风是第三大死因。本文通过案例情景检查了女性在整个生命周期中特有的心血管危险因素，并描述了一种基于精准医学的危险因素改变和一级预防方法。本文还介绍了基因检测和多基因风险评分在中风和心血管疾病预测中的作用的最新更新。
