Department of Physical Education, Sport and Human Movement, Universidad Autónoma de Madrid, Spain; IMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.
PROFITH "PROmoting FITness and Health through physical activity" research group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain; Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden.
Mayo Clin Proc. 2019 Nov;94(11):2209-2219. doi: 10.1016/j.mayocp.2019.04.042. Epub 2019 Oct 13.
To examine the association between physical activity (PA) and the risk for metabolically unhealthy obesity (MUO) or metabolically healthy obesity (MHO) in Asian adults.
Data were obtained from 205,745 healthy individuals 18 years or older. Individuals were classified as inactive, lower or upper insufficiently active, active, and high active. Metabolically unhealthy was defined as having 1 or more of the metabolic syndrome criteria, excluding the abdominal obesity criterion.
The percentages of metabolically healthy normal-weight (MHNW), metabolically healthy overweight (MHOW), MHO, and MUO in our cohort were 30.8% (63,408 of 205,745), 5.8% (12,002 of 205,745), 4.1% (8329 of 205,745), and 20.7% (42,564 of 205,745), respectively. During a mean follow-up of 6 (range, 0.5-19) years, among 63,408 MHNW participants, 1890 (3.0%) and 1174 (1.9%) developed MUO and MHO, respectively. Among 12,002 MHOW participants, 3404 (28.4%) developed MUO and 2734 (22.8%) developed MHO. A total of 5506 of 8329 (66.1%) participants moved from MHO to MUO, and 5675 of 42,564 (13.3%) moved from MUO to MHO. Compared with being inactive, MHNW individuals who were active or high active showed lower risk for MUO. Among those with MHOW, being high active was associated with reduced risk for MUO and MHO. Although among MHO participants, PA was not associated with incident MUO, being active or high active was linked to a greater likelihood of moving from MUO to MHO.
PA may prevent the development of both MHO and MUO. PA also helps increase the transition from MUO to MHO, which may contribute to reduce the subsequent development of type 2 diabetes mellitus and major cardiovascular disease complications.
探讨亚洲成年人身体活动（PA）与代谢不健康肥胖（MUO）或代谢健康肥胖（MHO）风险之间的关系。
数据来自 205745 名 18 岁或以上的健康个体。个体被归类为不活动、低或低不足活动、活跃和高活跃。代谢不健康定义为存在 1 种或多种代谢综合征标准，不包括腹部肥胖标准。
我们队列中代谢健康正常体重（MHNW）、代谢健康超重（MHOW）、MHO 和 MUO 的百分比分别为 30.8%（63408/205745）、5.8%（12002/205745）、4.1%（8329/205745）和 20.7%（42564/205745）。在平均 6 年（范围 0.5-19 年）的随访期间，在 63408 名 MHNW 参与者中，分别有 1890 名（3.0%）和 1174 名（1.9%）发生 MUO 和 MHO。在 12002 名 MHOW 参与者中，分别有 3404 名（28.4%）和 2734 名（22.8%）发生 MUO 和 MHO。共有 5506 名/8329 名（66.1%）参与者从 MHO 转为 MUO，5675 名/42564 名（13.3%）参与者从 MUO 转为 MHO。与不活动相比，活跃或高活跃的 MHNW 个体发生 MUO 的风险较低。在 MHOW 人群中，高活跃与 MUO 和 MHO 风险降低相关。尽管在 MHO 参与者中，PA 与新发 MUO 无关，但活跃或高活跃与从 MUO 转为 MHO 的可能性增加相关。
PA 可能预防 MHO 和 MUO 的发生。PA 还有助于增加从 MUO 向 MHO 的转变，这可能有助于减少随后发生 2 型糖尿病和主要心血管疾病并发症的风险。
