Heidarpour Maryam, Rezvanian Hassan, Kachuei Ali
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2019 Sep 30;24:81. doi: 10.4103/jrms.JRMS_969_18. eCollection 2019.
Acromegaly is a rare chronic disease and associated with an increased risk of malignancy. The issue of the risk of thyroid cancer in these patients is a topic of debate, and the number of large case-control studies is very limited. Several studies indicated that a chronic excess insulin-like growth factor-1 stimulates the proliferation of various cell types and induces an antiapoptotic effect in thyroid follicular cells. In the literature, the risk of thyroid cancer was reported greater than five-fold. In this review, we will briefly summarize the studies available regarding thyroid cancer in patients with acromegaly and present three case reports.
肢端肥大症是一种罕见的慢性疾病，与恶性肿瘤风险增加相关。这些患者患甲状腺癌的风险问题是一个有争议的话题，大型病例对照研究的数量非常有限。几项研究表明，长期过量的胰岛素样生长因子-1会刺激各种细胞类型的增殖，并在甲状腺滤泡细胞中诱导抗凋亡作用。在文献中，甲状腺癌的风险报告超过五倍。在本综述中，我们将简要总结有关肢端肥大症患者甲状腺癌的现有研究，并呈现三例病例报告。
