Khawar Muhammad Babar, Gao Hui, Li Wei
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Front Cell Dev Biol. 2019 Sep 18;7:195. doi: 10.3389/fcell.2019.00195. eCollection 2019.
During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals. The acrosome is a special kind of organelle with a cap-like structure that covers the anterior portion of the head of the spermatozoon. The acrosome is derived from the Golgi apparatus and contains digestive enzymes. With the progress of our understanding of acrosome biogenesis, a number of models have been proposed to address the origin of the acrosome. The acrosome has been regarded as a lysosome-related organelle, and it has been proposed to have originated from the lysosome or the autolysosome. Our review will provide a brief historical overview and highlight recent findings on acrosome biogenesis in mammals.
在有性生殖过程中，两个单倍体配子融合形成受精卵，顶体对于动物的这种融合过程（受精）至关重要。顶体是一种特殊的细胞器，具有帽状结构，覆盖精子头部的前部。顶体源自高尔基体，含有消化酶。随着我们对顶体生物发生理解的进展，已经提出了许多模型来解释顶体的起源。顶体被认为是一种与溶酶体相关的细胞器，有人提出它起源于溶酶体或自溶酶体。我们的综述将提供一个简要的历史概述，并突出哺乳动物顶体生物发生的最新发现。
