计算方法在麻醉药物发现中的应用

Computational Approaches to Anesthetic Drug Discovery.

机构信息

Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

出版信息

Trends Pharmacol Sci. 2019 Nov;40(11):809-811. doi: 10.1016/j.tips.2019.09.001. Epub 2019 Oct 14.

DOI:10.1016/j.tips.2019.09.001

Abstract

All currently available general anesthetics produce potentially deadly side effects. Unfortunately, few approaches have been developed to design safer ones, despite important advances in anesthetic mechanisms research. Cayla and colleagues recently showed that computational methods can be used to identify anesthetic lead compounds devoid of specific side effects.

摘要

目前所有可用的全身麻醉剂都会产生潜在致命的副作用。不幸的是，尽管在麻醉机制研究方面取得了重要进展，但设计更安全的麻醉剂的方法却寥寥无几。Cayla 及其同事最近表明，计算方法可用于识别不含特定副作用的麻醉先导化合物。