MAIT 细胞的 TCR 依赖性组织修复潜能。
A TCR-Dependent Tissue Repair Potential of MAIT Cells.
机构信息
INSERM U932, PSL University, Institut Curie, Paris 75005, France.
INSERM U932, PSL University, Institut Curie, Paris 75005, France; Laboratoire d'Immunologie Clinique, Institut Curie, Paris 75005, France; Centre d'Investigation Clinique en Biothérapie Gustave-Roussy Institut Curie (CIC-BT1428), Paris 75005, France.
出版信息
Trends Immunol. 2019 Nov;40(11):975-977. doi: 10.1016/j.it.2019.09.001. Epub 2019 Oct 14.
Three studies published in Cell Reports (Hinks et al., Lamichhane et al., and Leng et al.) describe the transcriptome of human and mouse mucosal-associated invariant T (MAIT) cells after cognate and noncognate stimulation. The results confirm the variability of MAIT cell effector functions and provide evidence of a new tissue-repair gene signature expressed upon T cell receptor (TCR) stimulation.
三篇发表在《Cell Reports》上的研究（Hinks 等人，Lamichhane 等人，以及 Leng 等人）描述了人类和小鼠黏膜相关不变 T（MAIT）细胞在同源和非同源刺激后的转录组。这些结果证实了 MAIT 细胞效应功能的可变性，并提供了证据表明，T 细胞受体（TCR）刺激后表达一种新的组织修复基因特征。
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