Maia Rosana, Neves Inês, Morais António, Queiroga Henrique
Departamento de Medicina Interna. Unidade Local de Saúde do Alto Minho. Hospital de Santa Luzia. Viana do Castelo. Portugal.
Serviço de Pneumologia. Hospital Padre Américo. Matosinhos. Portugal.
Acta Med Port. 2019 Oct 1;32(10):647-653. doi: 10.20344/amp.10260.
The relationship between cancer and thromboembolic events has been known for a long time. Lung and venous thromboembolism are frequent complications of lung cancer and its treatment, being a great cause of morbidity and mortality. We pretend to establish the relationship between lung and venous thromboembolism and lung cancer, describe patient characteristics and analyze the impact in the survival and prognosis.
It was a retrospective study. All research subjects were selected from lung cancer patients with a newly diagnosed lung and venous thromboembolism event admitted to Hospital S. João, between January 2008 and December 2013 and were followed until December 2014. Statistical analysis was performed with SPSS.
From the search, we obtained 113 patients. The majority was male, smokers or ex-smokers, and adenocarcinoma was the most frequent histologic type, being diagnosed mostly in advanced stages. We noticed that the median time between lung cancer diagnosis and lung venous thromboembolism was 2.9 months. In 24 patients (21.4%), the lung cancer diagnosis occurred after the lung and venous thromboembolism event and in 86 patients (76.8%), it occurred before the event. After a median follow up of 1.4 months, 107 (94.7%) patients died, 1 (0.9%) was lost to follow-up and 5 (4.4%) were still alive. The median survival rate was 1.5 months.
The diagnosis of lung and venous thromboembolism in patients with lung cancer is associated with bad prognosis. It occurs most frequently in patients with advanced disease, in the first months after lung cancer diagnosis and after beginning chemotherapy.
Disease progression is an independent predictor with negative impact in overall survival.
癌症与血栓栓塞事件之间的关系早已为人所知。肺血栓栓塞和静脉血栓栓塞是肺癌及其治疗的常见并发症，是发病和死亡的重要原因。我们旨在确立肺血栓栓塞和静脉血栓栓塞与肺癌之间的关系，描述患者特征，并分析其对生存和预后的影响。
这是一项回顾性研究。所有研究对象均选自2008年1月至2013年12月期间入住圣若昂医院的新诊断为肺血栓栓塞和静脉血栓栓塞事件的肺癌患者，并随访至2014年12月。使用SPSS进行统计分析。
通过检索，我们获得了113例患者。大多数为男性，吸烟者或曾经吸烟者，腺癌是最常见的组织学类型，大多在晚期被诊断出来。我们注意到肺癌诊断与肺静脉血栓栓塞之间的中位时间为2.9个月。在24例患者（21.4%）中，肺癌诊断发生在肺血栓栓塞和静脉血栓栓塞事件之后，而在86例患者（76.8%）中，发生在该事件之前。经过中位随访1.4个月后，107例（94.7%）患者死亡，1例（0.9%）失访，5例（4.4%）仍存活。中位生存率为1.5个月。
肺癌患者发生肺血栓栓塞和静脉血栓栓塞的诊断与不良预后相关。它最常发生在晚期疾病患者中，在肺癌诊断后的头几个月以及开始化疗后。
疾病进展是总体生存的一个具有负面影响的独立预测因素。
