INFIQC, CONICET and Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Dpto. Química Orgánica. Ciudad Universitaria, Medina Allende esq. Haya de la Torre s/n, 5000, Córdoba, Argentina; ICYTAC, CONICET and Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Dpto. Química Orgánica. Ciudad Universitaria, Bv. Juan Filloy s/n, 5000, Córdoba, Argentina.
CIBICI, CONICET and Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Dpto. Bioquímica Clínica. Ciudad Universitaria, Medina Allende esq. Haya de la Torre s/n, 5000, Córdoba, Argentina.
Chemosphere. 2020 Feb;241:125057. doi: 10.1016/j.chemosphere.2019.125057. Epub 2019 Oct 9.
Pharmaceuticals in the environment have been an increasing research topic over the past decade, since they can be found in both natural and drinking water, including irrigation of crops and edible plants with contaminated water. Our main goal was to evaluate the phytotoxic effect of diclofenac (DCF), a widely used pharmaceutical, on chicory (Cichorium intybus) seedlings. Additionally, we verified the uptake, bioconcentration and translocation of DCF from soil to chicory tissues. Results show that DCF induces different physiological changes in chicory seedlings. On the other hand, the soil-chicory experiment showed the activation of the detoxification system in plants treated with DCF (1 mg L). Finally, we found the migration of DCF from the irrigation water to the soil, followed by its uptake through the root, and its translocation to the aerial part of the chicory. However, DCF does not bioaccumulate in chicory leaves, being scarcely translocated from roots to aerial parts. This last result, along with the estimation of a daily intake of chicory, show that irrigation with water containing DCF (≤1 mg L) does not represent a threat to human health. To our knowledge, this is the first report on the effect of DCF on chicory seedlings, including the evaluation of its uptake and translocation.
在过去的十年中，环境中的药品一直是一个日益受到关注的研究课题，因为它们既存在于自然水中，也存在于饮用水中，包括用受污染的水灌溉作物和食用植物。我们的主要目标是评估一种广泛使用的药物双氯芬酸 (DCF) 对菊苣 (Cichorium intybus) 幼苗的植物毒性作用。此外，我们还验证了 DCF 从土壤向菊苣组织中的吸收、生物浓缩和迁移。结果表明，DCF 会引起菊苣幼苗发生不同的生理变化。另一方面，土壤-菊苣实验表明，用 DCF（1mg/L）处理的植物激活了解毒系统。最后，我们发现 DCF 从灌溉水中迁移到土壤中，然后通过根部被吸收，并转移到菊苣的地上部分。然而，DCF 不会在菊苣叶片中生物累积，很少从根部转移到地上部分。这最后一个结果，以及对菊苣每日摄入量的估计，表明用含有 DCF（≤1mg/L）的水灌溉不会对人类健康构成威胁。据我们所知，这是首次报道 DCF 对菊苣幼苗的影响，包括对其吸收和迁移的评估。
