[液氮冷冻减薄后牛心包性能的评估]
[Evaluation of bovine pericardium performance after liquid nitrogen freezing and thinning].
作者信息
Jin Chang, Wu Zebin, Jin Yongfu, Wang Lizhen, Zhong Shengping, Fan Yubo
机构信息
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, P.R.China;Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing 102402, P.R.China.
KingstronBio (Changshu) Co., Ltd, Changshu, Jiangsu 215500, P.R.China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019 Oct 25;36(5):827-833. doi: 10.7507/1001-5515.201901033.
In the present study, the performance of the liquid nitrogen frozen and thinned bovine pericardium was studied and compared with the porcine pericardium. The microstructure and mechanical properties of the bovine pericardium were observed and tested by hematoxylin-eosin (HE) staining and tensile test respectively. In all conditions, porcine pericardium was selected as a control group. The results showed that there was little difference in the performance of bovine pericardium after being frozen by liquid nitrogen. The secant modulus and ultimate strength of the thinned bovine pericardium were similar to those of porcine pericardium, however, the elastic modulus was a little higher than porcine pericardium. The study suggested that the performance of the thinned bovine pericardium was similar to those of porcine pericardium. It was easy for the thinned bovine pericardium to obtain a relatively ideal thickness and expected performance, therefore, the thinned bovine pericardium can be used as the materials of transcatheter aortic valve leaflets.
在本研究中，对液氮冷冻并减薄的牛心包的性能进行了研究，并与猪心包进行了比较。分别通过苏木精-伊红（HE）染色和拉伸试验观察和测试了牛心包的微观结构和力学性能。在所有条件下，均选择猪心包作为对照组。结果表明，液氮冷冻后的牛心包性能差异不大。减薄牛心包的割线模量和极限强度与猪心包相似，然而，其弹性模量略高于猪心包。该研究表明，减薄牛心包的性能与猪心包相似。减薄牛心包易于获得相对理想的厚度和预期性能，因此，减薄牛心包可作为经导管主动脉瓣叶的材料。
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