Granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) are glycosylated polypeptides that induce an increase in the proliferation and maturation of white blood cells including neutrophils and monocytes-macrophages. Recombinant forms of these colony stimulating factors are used to treat severe neutropenia in patients receiving cancer chemotherapy or undergoing hematopoietic cell transplantation. Recombinant forms include filgrastim (G-CSF) and sargramostim (GM-CSF), both of which are commercially available for therapy of severe neutropenia and bone marrow failure. Neither filgrastim nor sargramostim have been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
粒细胞集落刺激因子（G-CSF）和粒细胞巨噬细胞集落刺激因子（GM-CSF）是糖基化多肽，可诱导包括中性粒细胞和单核巨噬细胞在内的白细胞增殖和成熟增加。这些集落刺激因子的重组形式用于治疗接受癌症化疗或进行造血细胞移植的患者的严重中性粒细胞减少症。重组形式包括非格司亭（G-CSF）和沙格司亭（GM-CSF），两者均可用于治疗严重中性粒细胞减少症和骨髓衰竭。在治疗期间，非格司亭和沙格司亭均未与血清酶升高或临床上明显的肝损伤相关联。
