Class of 2020, University of Central Florida College of Medicine, Orlando, FL, USA.
Pediatric Urology, Nemours Children's Hospital, Orlando, FL, USA.
Expert Opin Pharmacother. 2019 Dec;20(18):2335-2352. doi: 10.1080/14656566.2019.1674282. Epub 2019 Oct 23.
: Non-neurogenic urinary incontinence in children is a common condition that affects the quality of life for both patients and parents. Symptoms may occur in the daytime, nighttime, or both and may be the result of structural and functional anomalies. Evaluation and management of associated co-morbidities, such as constipation is critical to management. Behavioral therapy is a fist line therapy in most cases of non-neurogenic urinary incontinence and pharmacologic therapy a second-line therapy.: In this review, the authors cover the pharmacologic agents, FDA approved and commonly used non-FDA approved, available for the treatment of four non-structural etiologies of non-neurogenic urinary incontinence in children. These include nocturnal enuresis, overactive bladder, giggle incontinence, and dysfunctional voiding.: Non-neurogenic causes of urinary incontinence in children represent a complicated medical condition that requires both pharmacologic and non-pharmacologic management. Limited FDA-approved therapies as well as suboptimal results with approved therapies due to a lack in the understanding of the underlying pathophysiology and patient selection may lead to the use of alternative non-FDA approved therapies.
儿童非神经源性尿失禁是一种常见病症，会影响患者和家长的生活质量。其症状可能发生在白天、晚上或两者兼有，可能是结构和功能异常的结果。评估和管理相关合并症（如便秘）对于治疗至关重要。行为疗法是大多数非神经源性尿失禁病例的一线治疗，药物疗法是二线治疗。在这篇综述中，作者介绍了用于治疗儿童非神经源性尿失禁四种非结构性病因的药物，包括夜间遗尿、膀胱过度活动症、笑尿失禁和功能性排尿障碍。儿童非神经源性尿失禁的病因较为复杂，需要药物和非药物治疗。由于对潜在病理生理学和患者选择的理解不足，有限的 FDA 批准的治疗方法以及批准的治疗方法效果不佳，可能导致使用替代的非 FDA 批准的治疗方法。
