Laboratory of Bacterial Pathogenicity, Faculty of Biological Sciences, University of Concepcion, Concepcion, Chile.
Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.
Biofouling. 2019 Sep;35(8):922-937. doi: 10.1080/08927014.2019.1675153. Epub 2019 Oct 24.
The ability to form biofilms and the potential immunomodulatory properties of the human gastric isolate UCO-25A were characterized . It was demonstrated that UCO-25A is able to form biofilms on abiotic and cell surfaces, and to modulate the inflammatory response triggered by infection in gastric epithelial cells and THP-1 macrophages. UCO-25A exhibited a substantial anti-inflammatory effect in both cell lines and improved IL-10 levels produced by challenged macrophages. Additionally, UCO-25A protected AGS cells against infection with a higher pathogen inhibition when a biofilm was formed. Given the importance of inflammation in mediated diseases, the differential modulation of the inflammatory response in the gastric mucosa by an autochthonous strain is an attractive alternative for improving eradication and reducing the severity of the diseases that arise from the resulting chronic inflammation.
该研究对人体胃分离株 UCO-25A 的生物膜形成能力和潜在的免疫调节特性进行了表征。结果表明，UCO-25A 能够在非生物和细胞表面形成生物膜，并调节由感染引起的胃上皮细胞和 THP-1 巨噬细胞的炎症反应。UCO-25A 在这两种细胞系中均表现出显著的抗炎作用，并提高了受刺激的巨噬细胞产生的 IL-10 水平。此外，当形成生物膜时，UCO-25A 可保护 AGS 细胞免受感染，对病原体的抑制作用更高。鉴于炎症在介导疾病中的重要性，源自定植菌的对胃黏膜炎症反应的差异调节，是改善根除率和减轻由持续炎症引起的疾病严重程度的一种有吸引力的替代方法。
