Characterization of the immunomodulatory and anti- properties of the human gastric isolate UCO-25A.

The ability to form biofilms and the potential immunomodulatory properties of the human gastric isolate UCO-25A were characterized . It was demonstrated that UCO-25A is able to form biofilms on abiotic and cell surfaces, and to modulate the inflammatory response triggered by infection in gastric epithelial cells and THP-1 macrophages. UCO-25A exhibited a substantial anti-inflammatory effect in both cell lines and improved IL-10 levels produced by challenged macrophages. Additionally, UCO-25A protected AGS cells against infection with a higher pathogen inhibition when a biofilm was formed. Given the importance of inflammation in mediated diseases, the differential modulation of the inflammatory response in the gastric mucosa by an autochthonous strain is an attractive alternative for improving eradication and reducing the severity of the diseases that arise from the resulting chronic inflammation.