Department of Developmental and Cell Biology, University of California, Irvine, California, USA.
Department of Developmental and Cell Biology, University of California, Irvine, California, USA; Department of Dermatology, University of California, Irvine, California, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, California USA.
J Invest Dermatol. 2019 Nov;139(11):2258-2260. doi: 10.1016/j.jid.2019.04.011.
Basosquamous carcinoma (BSC) is a rare form of skin cancer with both basaloid and squamous morphology. Chiang et al. (2019) genetically define BSCs and demonstrate that BSCs likely originate as basal cell carcinomas that partially squamatize through accumulation of ARID1A mutations and RAS/MAPK pathway activation.
基底鳞状细胞癌（BSC）是一种罕见的皮肤癌，具有基底样和鳞状两种形态。 Chiang 等人（2019 年）通过基因定义了 BSCs，并证明 BSCs 可能起源于基底细胞癌，通过 ARID1A 突变的积累和 RAS/MAPK 途径的激活部分鳞状化生。
