初免三剂乙型肝炎疫苗后延迟产生血清保护力而非无应答的病例报告。
Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination.
机构信息
Department of Medical Microbiology, School of NUTRIM, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands; Department of Gastro-Enterology and Hepatology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Martelarenlaan 42, 3500 Hasselt, Belgium.
Central Diagnostic Laboratory, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands.
出版信息
Vaccine. 2020 Jan 10;38(2):112-114. doi: 10.1016/j.vaccine.2019.10.022. Epub 2019 Oct 21.
We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination.
我们描述了一名 57 岁男性冒烟型多发性骨髓瘤患者在初次疫苗接种方案后 12 周出现乙型肝炎表面抗体延迟保护。由于第三次接种后 6 周抗-HBs 抗体无法检测到，该患者之前被认为是乙型肝炎疫苗无应答者。由于乙型肝炎疫苗接种始于 20 世纪 80 年代，许多乙型肝炎疫苗无应答者已接受了再接种方案。如果在血液恶性肿瘤患者中出现更多真正的乙型肝炎表面抗体延迟保护的病例，在开始乙型肝炎再接种之前应考虑延迟保护。
Zotero 插件