Chung Jin Ook, Park Seon-Young, Chung Dong Jin, Chung Min Young
Division of Endocrinology and Metabolism.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, Republic of Korea.
Medicine (Baltimore). 2019 Oct;98(43):e17693. doi: 10.1097/MD.0000000000017693.
This study sought to assess the hypothesis that anemia is associated with diabetic retinopathy in type 2 diabetes mellitus (DM) and investigate the factors mediating the relationship between anemia and diabetic retinopathy.In total, 1637 individuals with type 2 DM were examined in a cross-sectional study. Anemia was defined as hemoglobin level <120 g/L in women and <130 g/L in men. A logistic regression model was used to determine the association between anemia and diabetic retinopathy.Anemia was more prevalent in individuals with diabetic retinopathy. Logistic regression analysis found a statistically significant association between anemia and diabetic retinopathy after adjustment for traditional risk factors (odds ratio, 1.44; 95% confidence interval, 1.10-1.89, P = .009). Further adjustment for serum bilirubin levels removed the statistically significant association.In individuals with type 2 DM, anemia is related to diabetic retinopathy, and its association may be mediated by a correlated change in serum bilirubin levels.
本研究旨在评估2型糖尿病（DM）患者中贫血与糖尿病视网膜病变相关的假说，并探究介导贫血与糖尿病视网膜病变之间关系的因素。在一项横断面研究中，共检查了1637例2型糖尿病患者。贫血定义为女性血红蛋白水平<120g/L，男性血红蛋白水平<130g/L。采用逻辑回归模型确定贫血与糖尿病视网膜病变之间的关联。贫血在糖尿病视网膜病变患者中更为普遍。逻辑回归分析发现，在对传统危险因素进行校正后，贫血与糖尿病视网膜病变之间存在统计学显著关联（比值比，1.44；95%置信区间，1.10-1.89，P=0.009）。进一步对血清胆红素水平进行校正后，消除了统计学显著关联。在2型糖尿病患者中，贫血与糖尿病视网膜病变相关，其关联可能由血清胆红素水平的相关变化介导。
