EFFECTS 262 Research Group, Department of Physiology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.
PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain.
Nutrients. 2019 Oct 24;11(11):2567. doi: 10.3390/nu11112567.
Vitamin D deficiency is a worldwide health problem that, in addition to its well-known negative effects on musculoskeletal health, has been related to a wide range of acute and chronic age-related diseases. However, little is known about the association of body composition with the active, hormonal form of vitamin D, 1,25-dihydroxyvitamin D plasma levels (1,25(OH)D). Therefore, the aim of this study was to investigate the association of 1,25(OH)D with body composition including lean and fat body mass as well as bone mineral density (BMD) in middle-aged sedentary adults. A total of 73 (39 women) middle-aged sedentary adults (53.7 ± 5.1 years old) participated in the current study. We measured weight and height, and we used dual energy X-ray absorptiometry to measure lean body mass, fat body mass and BMD. Body mass index (BMI), lean mass index (LMI), and fat mass index (FMI) were calculated. 1,25(OH)D was measured using a DiaSorin Liaison® immunochemiluminometric analyzer. The results showed a negative association of 1,25(OH)D with BMI, LMI and BMD (β = -0.274, R = 0.075, = 0.019; β = -0.268, R = 0.072, = 0.022; and β = -0.325, R = 0.105, = 0.005, respectively), which persisted after controlling for age and sex. No significant differences in 1,25(OH)D across body weight status were observed after controlling for the same covariates. In summary, our results suggest that 1,25(OH)D could be negatively associated with BMI, LMI and BMD whereas no association was found with FMI in middle-aged sedentary adults.
维生素 D 缺乏是一个全球性的健康问题，除了众所周知的对骨骼肌肉健康的负面影响外，还与广泛的急性和慢性与年龄相关的疾病有关。然而，人们对身体成分与维生素 D 的活性、激素形式，1,25-二羟维生素 D 血浆水平（1,25(OH)D）之间的关系知之甚少。因此，本研究旨在探讨 1,25(OH)D 与身体成分的关系，包括瘦体重和脂肪体重以及骨密度（BMD）在中年久坐成年人中的关系。共有 73 名（39 名女性）中年久坐成年人（53.7 ± 5.1 岁）参加了本研究。我们测量了体重和身高，并使用双能 X 射线吸收法测量了瘦体重、脂肪体重和 BMD。计算了体重指数（BMI）、瘦体重指数（LMI）和脂肪体重指数（FMI）。使用 DiaSorin Liaison®免疫化学发光分析仪测量 1,25(OH)D。结果显示，1,25(OH)D 与 BMI、LMI 和 BMD 呈负相关（β = -0.274，R = 0.075，P = 0.019；β = -0.268，R = 0.072，P = 0.022；β = -0.325，R = 0.105，P = 0.005），控制年龄和性别后仍存在相关性。控制相同协变量后，1,25(OH)D 在体重状况之间无显著差异。总之，我们的研究结果表明，1,25(OH)D 可能与 BMI、LMI 和 BMD 呈负相关，而与中年久坐成年人的 FMI 无关。
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