Hayton Philip J, Whittington Richard J, Wakelin Colin, Colville Paul, Reid Aoife, Borja Leo, Toribio Jenny-Ann
School of Veterinary Science and Marie Bashir Institute for Infectious Diseases and Biosecurity, Farm Animal Health, University of Sydney, Camden, NSW 2570, Australia.
Koronivia Research Station, P.O. Box 77 Koronivia, Western Division, Fiji.
Vet Sci. 2019 Oct 24;6(4):85. doi: 10.3390/vetsci6040085.
The presence of a wildlife reservoir for complicates the eradication of bovine tuberculosis (BTB) from domestic cattle populations. For the BTB eradication program in Fiji, there is concern about the small Indian mongoose (), which is overabundant and in direct contact with cattle. Consequently, a survey of mongooses trapped on three BTB affected dairy farms led to necropsy of 85 mongooses during January-February 2017. Thirty (35%) mongooses had gross pathological changes including possible granulomas detected at necropsy, and tissues from these animals were taken for histopathological examination. Granulomatous lesions were present in 53% of animals examined histopathologically but acid-fast bacilli were not observed and the majority of lesions in lung and kidney were associated with the nematodes and sp., respectively. Nevertheless, assuming test sensitivity of 35% for the current study, from this sample of 85 mongooses it can be concluded with 95% confidence that if present in the mongoose population susceptible to trapping, prevalence was ≤10%. The prevalence of intercurrent lesions raised concerns about gross pathology as a screening test for infection in mongooses in Fiji, and therefore pathogen detection methods such as bacterial culture and direct tissue PCR are recommended for future surveys. These are needed to completely rule out the mongoose as a reservoir host for in Fiji.
野生动物宿主的存在使从家牛群体中根除牛结核病（BTB）变得复杂。对于斐济的牛结核病根除计划，人们担心印度小爪水獭数量过多且与牛有直接接触。因此，对在三个受牛结核病影响的奶牛场捕获的水獭进行了一项调查，在2017年1月至2月期间对85只水獭进行了尸检。30只（35%）水獭有肉眼可见的病理变化，包括尸检时可能发现的肉芽肿，这些动物的组织被用于组织病理学检查。在接受组织病理学检查的动物中，53%有肉芽肿性病变，但未观察到抗酸杆菌，肺和肾中的大多数病变分别与线虫和 sp.有关。然而，假设本研究的检测敏感性为35%，从这85只水獭的样本中可以有95%的把握得出结论：如果在易被捕获的水獭群体中存在 ，其患病率≤10%。并发病变的患病率引发了人们对将肉眼病理学作为斐济水獭 感染筛查试验的担忧，因此建议在未来的调查中采用细菌培养和直接组织PCR等病原体检测方法。需要这些方法来完全排除水獭作为斐济 的储存宿主。
