Gage J P, Francis M J, Smith R
Department of Restorative Dentistry, University of Queensland Dental School, Brisbane, Australia.
J Dent Res. 1988 Aug;67(8):1097-102. doi: 10.1177/00220345880670080701.
Amino acid analyses were carried out on dentin proteins obtained from 33 normal teeth and 59 teeth from osteogenesis imperfecta patients. The analyses revealed that in the control teeth approximately 95% of the insoluble dentin fraction was collagen. The majority of the analyses for teeth obtained from the O.I. patients were biochemically abnormal (55 out of 59). Specifically, there was a significant increase in the acidic amino acids, with a corresponding decrease in the basic amino acids. A small group of patients showed double peaks in the histidine, hydroxylysine, and lysine areas of the chromatograms. These results emphasize that despite the fact that the teeth of O.I. patients may appear to be clinically normal, all but four of the teeth examined had abnormal dentin collagen.
对取自33颗正常牙齿和59颗成骨不全症患者牙齿的牙本质蛋白进行了氨基酸分析。分析显示，在对照牙齿中，约95%的不溶性牙本质部分是胶原蛋白。对成骨不全症患者牙齿的大多数分析在生化方面是异常的（59颗中有55颗）。具体而言，酸性氨基酸显著增加，碱性氨基酸相应减少。一小部分患者的色谱图在组氨酸、羟赖氨酸和赖氨酸区域出现双峰。这些结果强调，尽管成骨不全症患者的牙齿在临床上可能看似正常，但除四颗牙齿外，所有检测的牙齿都有异常的牙本质胶原蛋白。
