Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.
Acta Ophthalmol. 2020 Feb;98(1):e56-e62. doi: 10.1111/aos.14200. Epub 2019 Oct 25.
The aim of our study was to compare metabolic (oxygen saturation; %) and anatomical parameters (retinal vessel diameter; μm) of retinal vessel oximetry (RO) in patients with cataract formation against those of healthy controls with clear lenses.
A total of 96 eyes of 62 subjects were examined: 51 eyes from 33 cataract patients (mean age: 64.8y) were compared to 45 eyes from 29 controls with clear lenses (mean age: 61.5y). RO was performed with the oxygen saturation measurement tool from the RVA (IMEDOS Systems UG). The oxygen saturation in all major peripapillary retinal arterioles (A-SO ) and venules (V-SO ) was measured, and their difference (A-V SO ) was calculated. In addition, the corresponding diameter in retinal arterioles (D-A) and venules (D-V) was evaluated. Cataract formation was graded according to the Lens Opacities Classification System III (LOCS III). Oximetry data were compared with the grade of cataract formation within both groups. For statistical evaluation, anova-based linear mixed-effects models were calculated (spss , pairwise comparisons: Bonferroni-corrected; p < 0.05).
Cataract eyes showed significantly lower A-SO and A-V SO values (mean ± SD 92.52 ± 9.80% and 28.56 ± 9.80%), when compared to healthy controls (95.47 ± 4.48% and 34.8 ± 7.08%; p = 0.046 and p = 0.001). Within the cataract group, cortical opacities showed significant interactions with the A-SO , V-SO and the A-V SO parameters (p = 0.027; p = 0.002; and p = 0.026, respectively).
These data indicate that the cataract-induced light scatter influences optical retinal oxygen measurements. Cortical opacities showed the highest influence on RO measurement when compared to nuclear opacification, nuclear colour and posterior cataract formation.
我们的研究旨在比较白内障形成患者的代谢（氧饱和度；%）和解剖参数（视网膜血管直径；μm）与健康对照组（透明晶状体）的参数。
共检查了 62 名受试者的 96 只眼：33 名白内障患者的 51 只眼（平均年龄：64.8 岁）与 29 名对照组的 45 只眼（平均年龄：61.5 岁）进行了比较。RO 使用 RVA（IMEDOS Systems UG）中的氧饱和度测量工具进行。测量了所有主要视盘周围视网膜动脉（A-SO）和小静脉（V-SO）的氧饱和度，并计算了它们之间的差异（A-V SO）。此外，还评估了视网膜动脉（D-A）和小静脉（D-V）的相应直径。白内障形成根据晶状体混浊分类系统 III（LOCS III）进行分级。在两组内，将氧饱和度数据与白内障形成的程度进行比较。对于统计评估，计算了基于 anova 的线性混合效应模型（spss，两两比较：Bonferroni 校正；p<0.05）。
与健康对照组相比（95.47 ± 4.48%和 34.8 ± 7.08%），白内障眼的 A-SO 和 A-V SO 值明显降低（平均值 ± 标准差 92.52 ± 9.80%和 28.56 ± 9.80%）（p=0.046 和 p=0.001）。在白内障组中，皮质混浊与 A-SO、V-SO 和 A-V SO 参数之间存在显著的相互作用（p=0.027；p=0.002；和 p=0.026，分别）。
这些数据表明，白内障引起的光散射会影响视网膜的光学氧测量。与核混浊、核色和后发性白内障形成相比，皮质混浊对 RO 测量的影响最大。
