Rees J L, Cox N H
Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, U.K.
Br J Dermatol. 1988 Jul;119(1):79-82. doi: 10.1111/j.1365-2133.1988.tb07105.x.
Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.
在20名患者中，测量了毛果芸香碱离子电渗疗法刺激下的汗液分泌率，分别在异维A酸治疗前和治疗期间进行测量。15名患者（75%）在治疗期间汗液分泌增加，但平均增加15%无统计学意义（配对t检验，P = 0.085；95%置信区间为 -0.2%至+30%），且没有患者有临床上明显的出汗改变。我们得出结论，异维A酸治疗不会引起刺激出汗的重要变化。
