Bhatia Alisha, Buvanendran Asokumar
Rush University Medical Center, Department of Anesthesiology, Chicago, Illinois, USA.
J Spine Surg. 2019 Sep;5(Suppl 2):S160-S165. doi: 10.21037/jss.2019.09.33.
Multimodal analgesia (MMA) involves the use of additive or synergistic combinations of analgesics to achieve clinically required analgesia while minimizing significant side effects associated with higher dose of a single equianalgesic medication such as an opioid analgesic. MMA generally involves optimizing non-opioid pharmacologic and non-pharmacologic interventions and reserving opioid use to treat breakthrough pain. Patients receiving medications via MMA protocols are likely to have lower opioid consumption compared to those managed using primarily IV opioid patient-controlled analgesia. MMA pain management strategies have become important components of enhanced recovery after surgery (ERAS) protocols in an effort to optimize care by standardizing analgesic medications in the perioperative setting while minimizing adverse effects and improving quality and patient outcomes. Successful implementation of a MMA requires the input and cooperation of all of the stakeholders including the caregivers as well as the patients. Health system benefits can also be realized from the implementation of an effective MMA, as fewer opioid related side effects can improve patient recovery and lead to faster discharge and improved utilization of resources.
多模式镇痛(MMA)涉及使用镇痛药的相加或协同组合,以实现临床所需的镇痛效果,同时将与高剂量单一等效镇痛药物(如阿片类镇痛药)相关的显著副作用降至最低。MMA通常包括优化非阿片类药物和非药物干预措施,并保留阿片类药物用于治疗爆发性疼痛。与主要使用静脉注射阿片类药物患者自控镇痛管理的患者相比,接受MMA方案治疗的患者可能阿片类药物消耗量更低。MMA疼痛管理策略已成为术后加速康复(ERAS)方案的重要组成部分,旨在通过在围手术期标准化镇痛药物来优化护理,同时将不良反应降至最低,并改善质量和患者预后。成功实施MMA需要所有利益相关者(包括护理人员和患者)的参与和合作。实施有效的MMA还可实现卫生系统效益,因为较少的阿片类药物相关副作用可改善患者康复情况,并导致更快出院和资源利用的改善。