Shiau Lie-Ding
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33302, Taiwan.
Department of Urology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.
ACS Omega. 2019 Oct 10;4(17):17352-17358. doi: 10.1021/acsomega.9b02102. eCollection 2019 Oct 22.
A new method of data interpretation based on classical nucleation theory is proposed in this work to elucidate the influence of solvents on the pre-exponential nucleation factor and interfacial energy using the induction time data for three crystallization systems, including isonicotinamide, lovastatin, and phenacetin. In this method, the pre-exponential nucleation factor is replaced by the intrinsic nucleation factor multiplied by temperature and divided by solution viscosity. The proposed method is applied to study the nucleation kinetics of isonicotinamide, lovastatin, and phenacetin among various solvents using the induction time data measured in this work. The results indicate that the intrinsic nucleation factor increases linearly with increasing square root of interfacial energy in various solvents for each system.
本工作提出了一种基于经典成核理论的数据解释新方法，以利用异烟酰胺、洛伐他汀和非那西丁三种结晶体系的诱导时间数据，阐明溶剂对指数前成核因子和界面能的影响。在该方法中，指数前成核因子被本征成核因子乘以温度再除以溶液粘度所取代。利用本工作中测得的诱导时间数据，将所提出的方法应用于研究异烟酰胺、洛伐他汀和非那西丁在各种溶剂中的成核动力学。结果表明，对于每个体系，在各种溶剂中，本征成核因子随界面能平方根的增加而线性增加。
