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Penetrance of Severe Pulmonary Arterial Hypertension in Response to Vascular Endothelial Growth Factor Receptor 2 Blockade in a Genetically Prone Rat Model Is Reduced by Female Sex.在遗传易患大鼠模型中，雌性可降低严重肺动脉高压对血管内皮生长因子受体2阻断的反应性。
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1
Inhibiting oestrogen signalling in pulmonary arterial hypertension: sex, drugs and research.抑制雌激素信号通路在肺动脉高压中的作用：性别、药物与研究
Eur Respir J. 2017 Aug 3;50(2). doi: 10.1183/13993003.00983-2017. Print 2017 Aug.
2
Pulmonary Arterial Hypertension and the Sex Hormone Paradox.肺动脉高压与性激素悖论。
Curr Hypertens Rep. 2016 Nov;18(11):84. doi: 10.1007/s11906-016-0689-7.
3
Estrogen Preserves Pulsatile Pulmonary Arterial Hemodynamics in Pulmonary Arterial Hypertension.雌激素可维持肺动脉高压患者的肺动脉搏动性血流动力学。
Ann Biomed Eng. 2017 Mar;45(3):632-643. doi: 10.1007/s10439-016-1716-1. Epub 2016 Aug 24.
4
Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.雌激素代谢物16α-羟基雌酮通过微小RNA-29介导的细胞代谢调节加重II型骨形态发生蛋白受体相关的肺动脉高压。
Circulation. 2016 Jan 5;133(1):82-97. doi: 10.1161/CIRCULATIONAHA.115.016133. Epub 2015 Oct 20.
5
Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones.雌二醇改善重度血管增殖性肺动脉高压大鼠的右心室功能：内源性和外源性性激素的作用
Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L873-90. doi: 10.1152/ajplung.00006.2015. Epub 2015 Feb 20.
6
Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure.新生儿高氧肺损伤可改善成年个体右心室对慢性低氧暴露的重塑反应。
Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L797-806. doi: 10.1152/ajplung.00276.2014. Epub 2015 Feb 6.
7
Sex-dependent influence of endogenous estrogen in pulmonary hypertension.内源性雌激素在肺动脉高压中的性别依赖性影响。
Am J Respir Crit Care Med. 2014 Aug 15;190(4):456-67. doi: 10.1164/rccm.201403-0483OC.
8
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension.雌激素在肺动脉高压实验模型中对右心室功能的直接和间接保护作用
Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H273-83. doi: 10.1152/ajpheart.00758.2013. Epub 2014 Jun 6.
9
Methods for measuring right ventricular function and hemodynamic coupling with the pulmonary vasculature.右心室功能和肺血管血流动力学耦联的测量方法。
Ann Biomed Eng. 2013 Jul;41(7):1384-98. doi: 10.1007/s10439-013-0752-3. Epub 2013 Feb 20.
10
Characterization of the isolated, ventilated, and instrumented mouse lung perfused with pulsatile flow.对灌注搏动血流的离体、通气和插管小鼠肺的特性描述。
J Vis Exp. 2011 Apr 29(50):2690. doi: 10.3791/2690.

Exogenous Estrogen Preserves Distal Pulmonary Arterial Mechanics and Prevents Pulmonary Hypertension in Rats.

作者信息

Philip Jennifer L, Tabima Diana M, Wolf Gregory D, Frump Andrea L, Cheng Tik-Chee, Schreier David A, Hacker Timothy A, Lahm Tim, Chesler Naomi C

机构信息

University of Wisconsin-Madison College of EngineeringMadison, Wisconsin.

University of Wisconsin-Madison School of Medicine and Public HealthMadison, Wisconsin.

出版信息

Am J Respir Crit Care Med. 2020 Feb 1;201(3):371-374. doi: 10.1164/rccm.201906-1217LE.

DOI:10.1164/rccm.201906-1217LE
PMID:31661294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6999110/
Abstract
摘要