Environmental Science and Technology Research Center, Department of Environmental Health Engineering, Shahid Sadoughi University of Medical Sciences, Yazd, Iran and Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran and Food, Drug and Cosmetics Safety Research Center, Kerman University of Medical Sciences, Kerman, Iran E-mail:
Water Sci Technol. 2019 Aug;80(4):685-694. doi: 10.2166/wst.2019.312.
Presence of emerging contaminants such as pharmaceutical products in aquatic environments has received high concern due to their undesirable effect on wildlife and human health. Current work deals with developing a treatment model based on the electro- Fenton (EF) process for efficient removal of metformin (MET) from an aqueous medium. The obtained experimental results revealed that over the reaction time of 10 min and solution pH of 3, the maximum removal efficiency of 98.57% is achieved where the value of MET initial concentration, current density, and HO dosage is set at 10 mg.L, 6 mA.cm, and 250 μL.L, respectively, which is in satisfactory agreement with the predicted removal efficiency of 98.6% with the desirability of 0.99. The presence of radical scavengers throughout the mineralization of MET under the EF process revealed that the generation of OH radicals, as the main oxidative species, controlled the degradation mechanism. The obtained kinetics data best fitted to the first order kinetic model with the rate constant of 0.4224 min (R = 0.9940). The developed treatment process under response surface methodology (RSM) was employed for modeling the obtained experimental data and successfully applied for efficient removal of the MET contaminant from pharmaceutical wastewater as an adequate and cost-effective approach.
由于医药产品等新兴污染物对野生动物和人类健康的不良影响，它们在水环境中的存在受到了高度关注。目前的工作是基于电芬顿（EF）工艺开发一种处理模型，以有效去除水溶液中的二甲双胍（MET）。实验结果表明，在反应时间为 10 分钟、溶液 pH 值为 3 的条件下，当 MET 初始浓度、电流密度和 HO 用量分别设定为 10mg/L、6mA/cm 和 250μL/L 时，最大去除效率可达 98.57%，与预测的去除效率 98.6%和理想值 0.99 非常吻合。在 EF 过程中，MET 的整个矿化过程中存在自由基清除剂，这表明 OH 自由基的生成作为主要的氧化物种控制着降解机制。得到的动力学数据与一级动力学模型拟合最好，速率常数为 0.4224 min（R=0.9940）。在响应面法（RSM）下开发的处理工艺用于对获得的实验数据进行建模，并成功应用于从制药废水中有效去除 MET 污染物，是一种充分且具有成本效益的方法。
