Beiersdorf AG, Research and Development, Hamburg, Germany.
Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Photodermatol Photoimmunol Photomed. 2020 Mar;36(2):135-144. doi: 10.1111/phpp.12523. Epub 2019 Nov 17.
Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products.
We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA).
Visible spectrum of 400-500 nm dose-dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm ). A pretreatment for 24 hours with 1 µmol/L LicA reduced ROS formation to the level of unirradiated cells while UV filters alone were ineffective, even at SPF50+. In vivo, topical treatment with a LicA-containing SPF50 + formulation significantly prevented the depletion of intradermal carotenoids by VIS irradiation while SPF50 + control did not protect.
LicA may be a useful additive antioxidant for sunscreens.
太阳辐射会通过生成活性氧（ROS）对皮肤造成损伤。虽然紫外线滤光剂能有效减少由 UV 引起的 ROS，但它们不能防止由 VIS（400-760nm）引起的氧化应激。因此，需要将强效抗氧化剂作为防晒霜的添加剂。
我们研究了 Nrf2 诱导剂LicA（LicA）对 VIS 诱导的 ROS 形成和光保护作用。
400-500nm 的可见光光谱以相当于夏日晴天（150J/cm ）1 小时阳光照射的剂量，剂量依赖性地诱导培养的人成纤维细胞中 ROS 的形成。用 1µmol/L 的 LicA 预处理 24 小时，可将 ROS 的形成降低到未照射细胞的水平，而单独使用紫外线滤光剂则无效，即使是 SPF50+也是如此。在体内，用含有 LicA 的 SPF50+制剂进行局部治疗可显著防止 VIS 照射引起的皮肤内类胡萝卜素耗竭，而 SPF50+对照则没有保护作用。
LicA 可能是防晒霜中有用的添加剂抗氧化剂。
