Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ren Fail. 2019 Nov;41(1):987-994. doi: 10.1080/0886022X.2019.1673775.
To evaluate the relationship between the aryl hydrocarbon receptor () rs2066853 gene polymorphism and the risk of male infertility. PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant case-control studies up to 31 July 2019. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the strength of associations. Finally, seven case-control studies involving 1247 cases and 1762 controls were included in this meta-analysis. The pooled results showed that there was no significant association between rs2066853 gene polymorphism and male infertility risk (A vs. G: OR = 1.08, 95% CI = 0.83-1.39; AA vs. GG: OR = 1.16, 95% CI = 0.65-2.04; AA vs. GA + GG: OR = 1.17, 95% CI = 0.66-2.07; AA + GA vs. GG: OR = 0.99, 95% CI = 0.85-1.15). Subgroup analysis by ethnicity showed the same result. However, significant association was found between rs2066853 gene polymorphism and male infertility risk in oligoasthenotspermia (A vs. G: OR = 2.52, 95% CI = 1.72-3.70). In conclusion, our meta-analysis indicated that rs2066853 gene polymorphism might be associated with an increased susceptibility to oligoasthenotspermia.
评估芳香烃受体（）rs2066853 基因多态性与男性不育风险之间的关系。
检索了 PubMed、Embase、Web of Science 和中国知网（CNKI）截至 2019 年 7 月 31 日的相关病例对照研究。采用比值比（OR）和 95%置信区间（95%CI）来评估关联强度。
最终，这项荟萃分析纳入了 7 项病例对照研究，共包含 1247 例病例和 1762 例对照。汇总结果显示，rs2066853 基因多态性与男性不育风险之间无显著关联（A 对. G：OR=1.08，95%CI=0.83-1.39；AA 对. GG：OR=1.16，95%CI=0.65-2.04；AA 对. GA+GG：OR=1.17，95%CI=0.66-2.07；AA+GA 对. GG：OR=0.99，95%CI=0.85-1.15）。按种族进行亚组分析，结果相同。然而，rs2066853 基因多态性与少弱精子症之间存在显著关联（A 对. G：OR=2.52，95%CI=1.72-3.70）。
本荟萃分析表明，rs2066853 基因多态性可能与少弱精子症易感性增加相关。
