Cheng Lin, Qian Long, Wang Guo-Sheng, Li Xiao-Mei, Li Xiang-Pei
Department of Rheumatology and Immunology, The Second Affiliated Hospital of Anhui Medical University Department of Rheumatology and Immunology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Medicine (Baltimore). 2017 Apr;96(15):e6392. doi: 10.1097/MD.0000000000006392.
The goal of this study was to evaluate the potential relationship among polymorphisms of aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor, and rheumatoid arthritis (RA) susceptibility as well as the association among the polymorphisms of aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor, and their expression.We performed a hospital-based, case-control study of 400 patients with RA and 726 healthy controls in Han Chinese populations. Two single-nucleotide polymorphisms were selected for genotyping including aromatic hydrocarbon receptor (rs2066853) and aromatic hydrocarbon receptor repressor (rs2292596).To single-nucleotide polymorphism rs2292596, a statistically significantly increased risk of RA was found to be associated with the G allele of rs2292596; the odds ratio was 2.170 (95% confidence interval: 1.820-2.587). Unfortunately, no significant differences exhibited in the allelic and the genotype frequencies of rs2066853 between 2 groups. We failed to find any association between rs2066853, rs2292596 genotypes and their expression of patients, respectively. No statistical relationship was found between aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor at messenger Ribonucleic acid levels and clinical data, either.This study demonstrated that the polymorphisms of rs2292596 was significant with genetic susceptibility to RA patients; furthermore, it suggests the G allele of rs2292596 might be associated with a dangerous effect on RA in Han Chinese populations.
本研究的目的是评估芳烃受体、芳烃受体阻遏物的多态性与类风湿关节炎（RA）易感性之间的潜在关系，以及芳烃受体、芳烃受体阻遏物的多态性与其表达之间的关联。我们在汉族人群中开展了一项基于医院的病例对照研究，纳入400例RA患者和726例健康对照。选择两个单核苷酸多态性进行基因分型，包括芳烃受体（rs2066853）和芳烃受体阻遏物（rs2292596）。对于单核苷酸多态性rs2292596，发现RA风险的统计学显著增加与rs2292596的G等位基因相关；比值比为2.170（95%置信区间：1.820 - 2.587）。遗憾的是，两组之间rs2066853的等位基因和基因型频率未表现出显著差异。我们分别未发现rs2066853、rs2292596基因型与其患者表达之间存在任何关联。在信使核糖核酸水平上，芳烃受体、芳烃受体阻遏物与临床数据之间也未发现统计学关系。本研究表明，rs2292596的多态性与RA患者的遗传易感性显著相关；此外，这表明rs2292596的G等位基因可能与汉族人群中RA的危险效应相关。
