枯草芽孢杆菌中进入稳定期生存的崎岖途径。

A Bumpy Pathway to Stationary-Phase Survival in Bacillus subtilis.

机构信息

Department of Microbiology and Cell Science, University of Florida, Space Life Sciences Laboratory, Merritt Island, Florida, USA

出版信息

mBio. 2019 Oct 29;10(5):e02461-19. doi: 10.1128/mBio.02461-19.

DOI:10.1128/mBio.02461-19

PMID:31662459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6819663/

Abstract

cells can mount a number of responses to nutritional deprivation but ultimately either form dormant spores or enter a metabolically quiescent state. In a recent article (mBio 10:e01414-19, https://doi.org/10.1128/mBio.01414-19, 2019), R. Hashuel and S. Ben-Yehuda report on a novel means by which nutrient-starved cells escape from aging (days-old) colonies by accumulating mutations enabling them to continue growth under nutrient-limited conditions. They postulate that such a strategy may be a major factor determining the dynamics of bacterial populations in natural environments.

摘要

细胞可以对营养缺乏做出多种反应，但最终要么形成休眠孢子，要么进入代谢静止状态。在最近的一篇文章（mBio 10:e01414-19，https://doi.org/10.1128/mBio.01414-19，2019）中，R. Hashuel 和 S. Ben-Yehuda 报道了一种新的方法，即营养饥饿的细胞通过积累突变来逃避衰老（几天龄）菌落，从而能够在营养有限的条件下继续生长。他们推测，这种策略可能是决定自然环境中细菌种群动态的主要因素。