iRhom2 和 TNF：伙伴还是敌人？
iRhom2 and TNF: Partners or enemies?
机构信息
Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal.
Centre for Cancer Research and Cell Biology, Queen's University, Belfast, UK.
出版信息
Sci Signal. 2019 Oct 29;12(605):eaaz0444. doi: 10.1126/scisignal.aaz0444.
iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor-α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of , Sundaram demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.
iRhom2 是 ADAM17 的必需辅助因子，ADAM17 是一种金属蛋白酶，可从细胞表面脱落促炎细胞因子肿瘤坏死因子-α (TNF-α) 和 TNF 受体 (TNFRs)。在本期的《自然》杂志中，Sundaram 证明了 iRhom2 在促进肝星状细胞中 ADAM17 介导的 TNFR 脱落中的保护作用，这可减少 TNFR 信号传导，并在受到损伤时减少肝纤维化。
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