3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece
3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
In Vivo. 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662.
BACKGROUND/AIM: Mixed adenoneuroendocrine carcinomas (MANEC) are uncommon tumors exhibiting both adenocarcinomatous and neuroendocrine differentiation. They most commonly arise in the colon, appendix, rectum or stomach, however, a limited number of MANECs have been reported to originate in the gallbladder (gMANEC). The aim of our systematic review was to accumulate the existing data on gMANEC with special attention to the clinicopathological characteristics, surgical approach, recurrence and survival rates of patients diagnosed with this rare malignancy.
A comprehensive search of the literature was undertaken.
A total of 15 studies (14 case reports and 1 case series), which comprised 19 patients who successfully underwent surgical treatment for gMANEC were included in our systematic review. During a median follow-up of 8 months (range=2-48 months) the overall survival was 87% and the recurrence rate was 21%.
Achievement of complete surgical resection is the mainstay of the therapeutic management. Additionally, the stage of the disease and the histopathological mapping of these tumors affect decision-making for adjuvant chemotherapy and seem to define the prognostic course of each patient.
背景/目的：混合性腺神经内分泌癌（MANEC）是一种罕见的肿瘤，同时具有腺癌和神经内分泌分化。它们最常发生在结肠、阑尾、直肠或胃，但也有少数 MANEC 报道起源于胆囊（gMANEC）。我们进行这项系统评价的目的是积累关于 gMANEC 的现有数据，特别关注诊断为这种罕见恶性肿瘤的患者的临床病理特征、手术方法、复发率和生存率。
我们进行了全面的文献检索。
共有 15 项研究（14 例病例报告和 1 例病例系列）纳入了这项系统评价，共包括 19 例成功接受手术治疗的 gMANEC 患者。在中位随访 8 个月（范围=2-48 个月）期间，总生存率为 87%，复发率为 21%。
实现完全手术切除是治疗管理的主要方法。此外，疾病的分期和这些肿瘤的组织病理学图谱影响辅助化疗的决策，并似乎定义了每个患者的预后过程。
