每周一次的老年乳腺癌Hypofractionated 放疗同步整合增敏：初步证据。
Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly: Preliminary Evidence.
机构信息
Department of Radiation Oncology, IRCCS Policlinico San Martino, Genoa, Italy
Department of Radiation Oncology, IRCCS Policlinico San Martino, Genoa, Italy.
出版信息
In Vivo. 2019 Nov-Dec;33(6):1985-1992. doi: 10.21873/invivo.11694.
AIM
To evaluate once-weekly hypofractionated radiotherapy in elderly patients affected by early breast cancer, reporting acute and late toxicity profiles, and treatment feasibility.
PATIENTS AND METHODS
Fifty patients were treated with a hypofractionated regimen: 28.5±2.5 Gy in five fractions at one fraction weekly. Simultaneous integrated boost (SIB) to the tumor bed in high-risk cases.
INCLUSION CRITERIA
patients over 70 years old, pT1-2, N0-1a. Acute and late toxicities were assessed based on Radiation Therapy Oncology Group.
RESULTS
The median follow-up was 20 months and the median patient age was 79 years. SIB was added for 22 patients (44%). Grade 3-4 acute cutaneous toxicities were not observed; grade 2 toxicity occurred only in four patients (8%). Late subcutaneous tissue toxicity consisted of grade 2 fibrosis in two patients (4%), grade 1 in five (10%) and grade 0 in 41(85%).
CONCLUSION
Limiting fraction numbers with a safer profile may improve the management of breast cancer for the elderly.
目的
评估每周一次的超分割放疗在老年早期乳腺癌患者中的应用，报告急性和晚期毒性概况以及治疗可行性。
患者和方法
50 例患者接受超分割方案治疗：28.5±2.5Gy，每周一次，共 5 次。高危病例采用肿瘤床同步整合 boost（SIB）。
纳入标准
年龄>70 岁，pT1-2，N0-1a。根据放射治疗肿瘤学组评估急性和晚期毒性。
结果
中位随访时间为 20 个月，中位患者年龄为 79 岁。22 例（44%）患者加用 SIB。未观察到 3-4 级急性皮肤毒性；仅 4 例（8%）患者出现 2 级毒性。晚期皮下组织毒性包括 2 例（4%）2 级纤维化，5 例（10%）1 级和 41 例（85%）0 级。
结论
限制分次次数可改善老年乳腺癌的管理，且安全性更佳。
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