韩国儿童脑瘤幸存者内分泌疾病的患病率。
Prevalence of Endocrine Disorders in Childhood Brain Tumor Survivors in South Korea.
机构信息
Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Republic of Korea.
Department of Pediatrics, Ajou University School of Medicine, Suwon, Republic of Korea.
出版信息
In Vivo. 2019 Nov-Dec;33(6):2287-2291. doi: 10.21873/invivo.11735.
BACKGROUND/AIM: This longitudinal study aimed to analyze the prevalence of endocrine disorders in childhood brain tumor survivors in South Korea using claims data.
PATIENTS AND METHODS
We identified in 1,058 patients from a nationwide cohort of patients diagnosed with brain tumors between January 1st 2009 to March 29th 2016. Multivariable logistic regression was used to evaluate associations between clinical factors and endocrine disorders.
RESULTS
After a median follow-up of 60.0 months, 393 (37.1%) patients had at least 1 endocrine disorder. The commonest endocrine disorders were hypopituitarism (17.4%) and hypothyroidism (6.1%). Female gender (odds ratio(OR)=1.45, p=0.005) and age <10 years (OR=1.65, p=0.001) conferred a higher risk. Patients who received radiotherapy were more likely to have endocrine disorders compared to those who did not (OR=1.79, p<0.001).
CONCLUSION
Regular assessment of endocrine function and timely interventions are necessary for childhood brain tumor survivors with a risk of endocrine disorders.
背景/目的：本纵向研究旨在使用索赔数据分析韩国儿童脑瘤幸存者内分泌紊乱的患病率。
患者与方法
我们从 2009 年 1 月 1 日至 2016 年 3 月 29 日期间被诊断患有脑瘤的全国性患者队列中，确定了 1058 名患者。多变量逻辑回归用于评估临床因素与内分泌紊乱之间的关联。
结果
中位随访 60.0 个月后，393 名（37.1%）患者至少存在 1 种内分泌紊乱。最常见的内分泌紊乱是垂体功能减退（17.4%）和甲状腺功能减退（6.1%）。女性（比值比[OR]=1.45，p=0.005）和<10 岁（OR=1.65，p=0.001）的年龄与更高的风险相关。与未接受放疗的患者相比，接受放疗的患者更有可能出现内分泌紊乱（OR=1.79，p<0.001）。
结论
对于有内分泌紊乱风险的儿童脑瘤幸存者，需要定期评估内分泌功能并及时干预。
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