一种用于治疗种植体周围疾病的抗菌牙科光固化生物粘附水凝胶。
An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases.
作者信息
Sani Ehsan Shirzaei, Lara Roberto Portillo, Aldawood Zahra, Bassir Seyed Hossein, Nguyen Daniel, Kantarci Alpdogan, Intini Giuseppe, Annabi Nasim
机构信息
Chemical and Biomolecular Engineering Department, University of California -Los Angeles, Los Angeles, CA 90095, USA.
Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Zapopan, JAL 44-49, México.
出版信息
Matter. 2019 Oct 2;1(4):926-944. doi: 10.1016/j.matt.2019.07.019. Epub 2019 Sep 11.
Dental implants constitute the standard of care to replace the missing teeth, which has led to an increase in the number of patients affected by peri-implant diseases (PIDs). Here, we report the development of an antimicrobial bioadhesive, GelAMP, for the treatment of PIDs. The hydrogel is based on a visible light-activated naturally-derived polymer (gelatin) and an antimicrobial peptide (AMP). The optimized formulation of GelAMP could be rapidly crosslinked using commercial dental curing systems. When compared to commercial adhesives, the bioadhesives exhibited significantly higher adhesive strength to physiological tissues and titanium. Moreover, the bioadhesive showed high cytocompatibility and could efficiently promote cell proliferation and migration . GelAMP also showed remarkable antimicrobial activity against . Furthermore, it could support the growth of autologous bone after sealing calvarial bone defects in mice. Overall, GelAMP could be used as a platform for the development of more effective therapeutics against PIDs.
牙种植体是缺失牙修复的标准治疗方法，这导致了种植体周围疾病（PID）患者数量的增加。在此，我们报告了一种用于治疗PID的抗菌生物粘合剂GelAMP的研发情况。该水凝胶基于一种可见光激活的天然聚合物（明胶）和一种抗菌肽（AMP）。GelAMP的优化配方可使用商用牙科固化系统快速交联。与商用粘合剂相比，这种生物粘合剂对生理组织和钛的粘合强度显著更高。此外，该生物粘合剂表现出高细胞相容性，能够有效促进细胞增殖和迁移。GelAMP对……也表现出显著的抗菌活性。此外，在封闭小鼠颅骨缺损后，它能够支持自体骨的生长。总体而言，GelAMP可作为开发更有效治疗PID药物的平台。
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