Ozen S Baltaci, Celebi S H, Coskun D, Gungor I, Inan G
Bratisl Lek Listy. 2019;120(10):789-793. doi: 10.4149/BLL_2019_132.
Lipid emulsions are promising with regard to the treatment of toxicity by agents of high lipophilic nature. Our objective is to investigate the efficacy of intralipid 20% and calcium administration at different times when symptoms of cardiac toxicity occur during verapamil infusion.
24 adult male Spraque-Dawley rats were randomly divided into 4 different groups, the control group, calcium group, calcium following 20% intralipid group and concomitant 20% intralipid and calcium group. Following monitoring under ketamine anesthesia, all groups were administered 37.5 mg kg-1 h-1 verapamil infusion until a 50% decrease occurred in MAPb. At the end of the infusion, verapamil infusion was decreased down to 15 mg kg-1h-1 and the treatment agents predetermined for the groups were administered concomitantly.
There is no statistically significant difference between the administration of 20% intralipid synchronized with calcium or as a pretreatment, but both groups provided a higher survival rate when compared to the other groups.
The administration of calcium alone in verapamil toxicity is not sufficient; when calcium and 20% intralipid are administered together, there is no difference between the administration of lipid and calcium concomitantly and the administration of lipid prior to calcium (Tab. 1, Fig. 2, Ref. 23).
脂质乳剂在治疗高亲脂性药物中毒方面具有前景。我们的目标是研究在维拉帕米输注期间出现心脏毒性症状时，不同时间给予20%脂肪乳和钙剂的疗效。
将24只成年雄性Spraque-Dawley大鼠随机分为4组，即对照组、钙剂组、20%脂肪乳后钙剂组和20%脂肪乳与钙剂联合组。在氯胺酮麻醉下进行监测后，所有组均以37.5mg·kg-1·h-1的速度输注维拉帕米，直至平均动脉压（MAPb）下降50%。输注结束时，将维拉帕米输注速度降至15mg·kg-1·h-1，并同时给予各组预先确定的治疗药物。
与钙剂同步或作为预处理给予20%脂肪乳，二者之间无统计学显著差异，但与其他组相比，这两组的生存率更高。
单独给予钙剂治疗维拉帕米中毒是不够的；当钙剂和20%脂肪乳一起给予时，脂肪乳与钙剂同时给药和脂肪乳在钙剂之前给药之间没有差异（表1，图2，参考文献23）。
