Outerridge P M, Cullen P R, Windon R G, Brown S
McMaster Laboratory, Glebe, New South Wales, Australia.
Anim Genet. 1988;19(2):159-69. doi: 10.1111/j.1365-2052.1988.tb00801.x.
Lymphocyte alloantigens were determined in 183 Australian merino sheep, using antisera from Australian and European laboratories. The study had two aims: (1) to compare reagents characterized in the different laboratories and to correlate antigen definition; and (2) to define lymphocyte antigens for use as genetic markers in two flocks of sheep which had been selectively bred for resistance or susceptibility to the intestinal parasite Trichostrongylus colubriformis, in order to extend a previous study which had indicated linkage between resistance to the parasite and the sheep major histocompatibility system. Good or excellent correspondence was found between four Australian and four European specificities and it was concluded that continued international collaboration would allow definition of markers for future genetic or disease susceptibility studies.
利用来自澳大利亚和欧洲实验室的抗血清，对183只澳大利亚美利奴绵羊的淋巴细胞同种抗原进行了测定。该研究有两个目的：（1）比较不同实验室鉴定的试剂并关联抗原定义；（2）在两群已针对肠道寄生虫蛇形毛圆线虫的抗性或易感性进行选择性培育的绵羊中定义用作遗传标记的淋巴细胞抗原，以扩展先前表明寄生虫抗性与绵羊主要组织相容性系统之间存在连锁关系的研究。在四种澳大利亚特异性和四种欧洲特异性之间发现了良好或极好的对应关系，得出的结论是，持续的国际合作将有助于为未来的遗传或疾病易感性研究定义标记。
