转移性鼻咽癌经动脉内联合静脉肽受体放射性核素治疗。
Metastatic Nasopharyngeal Carcinoma Treated With Intraarterial Combined With Intravenous Peptide Receptor Radionuclide Therapy.
机构信息
From the Theranostics Center for Molecular Radiotherapy and Precision Oncology, ENETS Center of Excellence, Zentralklinik Bad Berka, Germany.
Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, CAMS and PUMC, Beijing, China.
出版信息
Clin Nucl Med. 2019 Dec;44(12):989-990. doi: 10.1097/RLU.0000000000002788.
Nasopharyngeal carcinoma may express somatostatin receptors (SSTR). We present a case with metastatic nasopharyngeal carcinoma in the liver, bone, and lymph nodes. The patient was in progression after chemotherapy, external beam radiation therapy (ERBT), atezolizumab, and cetuximab. Due to strong SSTR expression of the metastases, PRRT was applied. After 3 cycles of intravenous Lu-DOTATOC and 1 cycle of intraarterial Y-DOTATOC therapy, the hepatic and bone metastases showed excellent response after PRRT. No nephrotoxicity or myelotoxicity was observed.
鼻咽癌可能表达生长抑素受体（SSTR）。我们报告了 1 例转移性鼻咽癌病例，其转移部位包括肝脏、骨骼和淋巴结。患者在接受化疗、外照射放疗（ERBT）、阿替利珠单抗和西妥昔单抗治疗后疾病进展。由于转移灶强烈表达 SSTR，故采用 PRRT 治疗。在静脉注射 Lu-DOTATOC 治疗 3 个周期和动脉内注射 Y-DOTATOC 治疗 1 个周期后，PRRT 治疗后肝脏和骨骼转移灶显示出极好的疗效。未观察到肾毒性或骨髓毒性。
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