载白介素 1 受体拮抗剂的葡聚糖/PLGA 微球的制备及其体外抑制牙周炎炎症的评价。
Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro.
机构信息
Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China.
出版信息
Inflammation. 2020 Feb;43(1):168-178. doi: 10.1007/s10753-019-01107-w.
Periodontitis is a chronic infectious disease, the course and progression of which are determined by the interaction between microorganisms and the host. Interleukin 1β plays an important role in the destruction of periodontal tissues. Interleukin 1 receptor antagonist (IL-1ra) can inhibit the biological activity of IL-1β without triggering any intracellular signaling. This study aimed to prepare IL-1ra-loaded dextran/PLGA microspheres and evaluate the physical and chemical characteristics and anti-inflammatory properties. Results suggested that the microspheres can be easily prepared into a drug carrier with good biocompatibility and can effectively inhibit the gene expression of pro-inflammatory factors induced by IL-1β in human gingival fibroblasts. Hence, the microspheres are excellent candidate for periodontitis treatment.
牙周炎是一种慢性感染性疾病，其病程和进展取决于微生物和宿主之间的相互作用。白细胞介素 1β 在牙周组织破坏中发挥重要作用。白细胞介素 1 受体拮抗剂（IL-1ra）可抑制 IL-1β 的生物学活性，而不触发任何细胞内信号。本研究旨在制备负载白细胞介素 1 受体拮抗剂（IL-1ra）的葡聚糖/PLGA 微球，并评价其理化性质和抗炎特性。结果表明，该微球可轻松制备成具有良好生物相容性的药物载体，能有效抑制白细胞介素 1β 诱导的人牙龈成纤维细胞促炎因子的基因表达。因此，该微球是治疗牙周炎的理想候选药物。
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