Zięba Magdalena, Chaber Paweł, Duale Khadar, Martinka Maksymiak Magdalena, Basczok Maciej, Kowalczuk Marek, Adamus Grazyna
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Skłodowska St., 41-800 Zabrze, Poland.
Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 6 Uniwersytetu Poznańskiego St., 61-614 Poznań, Poland.
Polymers (Basel). 2020 Jul 15;12(7):1574. doi: 10.3390/polym12071574.
Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.
牙周炎（PD）是一种由致病微生物引起的牙周组织慢性炎症性疾病，其特征是牙齿支持结构遭到破坏。牙周疾病治疗中的传统给药途径存在诸多缺点，如生物分布不佳、治疗效果选择性低、药物突释以及对健康细胞的损伤等。为克服这一局限性，已开发出控释给药系统作为治疗口腔感染性疾病的一种潜在方法。事实证明，使用给药装置是提高包括难以触及的牙周袋在内的牙周炎治疗质量和效果的一种出色辅助方法。本综述探讨了各种基于聚合物的给药系统，如水凝胶、脂质体、微纳米颗粒在慢性牙周病治疗中的应用现状。此外，为更全面地理解牙周炎治疗所面临的困难，还概述了该疾病的发病机制及发展情况。
