Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Centre for Orthopaedic Research, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA, 6009, Australia.
BMC Musculoskelet Disord. 2019 Oct 30;20(1):501. doi: 10.1186/s12891-019-2873-9.
Charcot neuroarthropathy is a systemic disease that generates pathological changes in the musculoskeletal system, causing instability, dislocations, and deformities. Charcot neuroarthropathy of the knee, due to either diabetes mellitus or syringomyelia, is anecdotally reported with the epidemic of the diseases. However, idiopathic sensory peripheral neuropathy can inflict osteoarticular structures directly, inducing a dysfunctional Charcot neuroarthropathy. An early diagnosis and effective relief of the symptomatic deformity is essential for the treatment.
We report the case of a patient with idiopathic sensory peripheral neuropathy who presented with a swelling right knee, as well as distorted and painless gait disorder, diagnosed as Charcot neuroarthropathy of the knee. Partial weight bearing with a hinged knee brace was used to correct the abnormal alignment and gait posture, and bisphosphonates were prescribed to decrease pathological bone resorption. Although the alignment and Knee Society Score got a gradual deterioration, the combination of orthosis and pharmacy could alleviate the symptom to a certain extent.
The diagnosis of Charcot neuroarthropathy of the knee is rare that requiring early diagnosis. The presence of features, including painlessness, numbness, and deformed arthropathy following chronic-onset algesthesia loss should be taken carefully.
夏科氏神经关节病是一种全身性疾病,会导致肌肉骨骼系统发生病理性改变,从而导致不稳定、脱位和畸形。膝夏科氏神经关节病,无论是由糖尿病还是脊髓空洞症引起,都有报道称与这些疾病的流行有关。然而,特发性感觉周围神经病可直接影响骨关节结构,导致功能失调的夏科氏神经关节病。早期诊断和有效缓解症状性畸形对于治疗至关重要。
我们报告了一例特发性感觉周围神经病患者,其右膝关节肿胀,步态扭曲且无痛,诊断为膝夏科氏神经关节病。使用带铰链的膝关节支具部分负重以纠正异常的对线和步态姿势,并开具了双膦酸盐类药物以减少病理性骨吸收。尽管对线和膝关节学会评分逐渐恶化,但矫形器和药物的联合应用可以在一定程度上缓解症状。
膝夏科氏神经关节病的诊断较为罕见,需要早期诊断。对于慢性发作性感觉丧失后出现无痛、麻木和畸形性关节炎的特征,应仔细考虑。