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伽玛刀治疗后听力损失——是耳蜗剂量还是放射工具的错!

Hearing loss after radiosurgery-blame it on Cochlear dose or the radiation tool!

机构信息

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.

Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

出版信息

Radiat Oncol. 2019 Oct 30;14(1):186. doi: 10.1186/s13014-019-1390-1.

DOI:10.1186/s13014-019-1390-1
PMID:31666089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6822357/
Abstract

While sudden hearing loss after stereotactic radiosurgery has been demonstrated in some cases a recent article by Linge et al. and have demonstrated the need for further discussion on this topic. We attempt to delineate the fact that the type of dosing regimen or technology used will not affect the hearing or radio-graphical control outcomes and thus should not be a consideration while administering treatment. Also we discuss the role of location of the lesion and vascularity and potential new therapies for this unexpected outcome after radiosurgery.

摘要

虽然立体定向放射外科后突发性听力损失在某些情况下已得到证实,但 Linge 等人的一篇近期文章表明,需要进一步讨论这个问题。我们试图阐明这样一个事实,即所使用的剂量方案类型或技术不会影响听力或放射学控制结果,因此在进行治疗时不应考虑这一点。我们还讨论了病变位置、血管以及放射外科治疗后这种意外结果的潜在新疗法的作用。

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Hearing loss after radiosurgery-blame it on Cochlear dose or the radiation tool!伽玛刀治疗后听力损失——是耳蜗剂量还是放射工具的错!
Radiat Oncol. 2019 Oct 30;14(1):186. doi: 10.1186/s13014-019-1390-1.
2
Cochlea radiation dose correlates with hearing loss after stereotactic radiosurgery of vestibular schwannoma.耳蜗剂量与听神经瘤立体定向放射外科治疗后听力损失相关。
World Neurosurg. 2013 Sep-Oct;80(3-4):359-63. doi: 10.1016/j.wneu.2012.04.001. Epub 2012 Apr 5.
3
Progression of hearing loss after LINAC-based stereotactic radiotherapy for vestibular schwannoma is associated with cochlear dose, not with pre-treatment hearing level.LINAC 立体定向放射治疗前庭神经鞘瘤后听力损失的进展与耳蜗剂量相关,而与治疗前听力水平无关。
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Increased cochlear radiation dose predicts delayed hearing loss following both stereotactic radiosurgery and fractionated stereotactic radiotherapy for vestibular schwannoma.立体定向放射外科和分次立体定向放射治疗前庭神经鞘瘤后,耳蜗放射剂量增加可预测听力延迟损失。
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J Neurosurg. 2013 Mar;118(3):571-8. doi: 10.3171/2012.10.JNS12880. Epub 2012 Dec 7.
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Fractionated stereotactic radiotherapy of vestibular schwannomas accelerates hearing loss.分次立体定向放射治疗前庭神经鞘瘤可加速听力损失。
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Gamma knife radiosurgery for vestibular schwannoma: early hearing outcomes and evaluation of the cochlear dose.伽玛刀放射外科治疗前庭神经鞘瘤:早期听力结果及耳蜗剂量评估
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本文引用的文献

1
Progression of hearing loss after LINAC-based stereotactic radiotherapy for vestibular schwannoma is associated with cochlear dose, not with pre-treatment hearing level.LINAC 立体定向放射治疗前庭神经鞘瘤后听力损失的进展与耳蜗剂量相关,而与治疗前听力水平无关。
Radiat Oncol. 2018 Dec 24;13(1):253. doi: 10.1186/s13014-018-1202-z.
2
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Radiosurgery and Radiation Therapy in the Management of Patients With Vestibular Schwannomas.神经外科医师协会系统评价和基于证据的指南:放射外科和放射治疗在管理前庭神经鞘瘤患者中的作用。
Neurosurgery. 2018 Feb 1;82(2):E49-E51. doi: 10.1093/neuros/nyx515.
3
Acute clinical adverse radiation effects after Gamma Knife surgery for vestibular schwannomas.伽玛刀手术后前庭神经鞘瘤的急性临床放射性不良反应。
J Neurosurg. 2016 Dec;125(Suppl 1):73-82. doi: 10.3171/2016.7.GKS161496.
4
Gamma Knife radiosurgery for vestibular schwannoma: clinical results at long-term follow-up in a series of 379 patients.伽玛刀放射外科治疗前庭神经鞘瘤:379例患者长期随访的临床结果
J Neurosurg. 2014 Dec;121 Suppl:123-42. doi: 10.3171/2014.8.GKS141506.
5
Hearing preservation after radiotherapy for vestibular schwannomas is comparable to hearing deterioration in healthy adults and is accompanied by local tumor control and a highly preserved quality of life (QOL) as patients' self-reported outcome.听神经瘤放疗后的听力保护可与健康成年人的听力下降相媲美,并且伴随着局部肿瘤控制和高度保留的生活质量(QOL),这是患者自我报告的结果。
Radiother Oncol. 2013 Feb;106(2):175-80. doi: 10.1016/j.radonc.2012.12.004. Epub 2013 Jan 17.
6
Hearing preservation in patients with vestibular schwannoma treated with Gamma Knife surgery.听神经瘤患者行伽玛刀手术后的听力保护。
J Neurosurg. 2013 Mar;118(3):571-8. doi: 10.3171/2012.10.JNS12880. Epub 2012 Dec 7.
7
Dosimetric comparison of different treatment modalities for stereotactic radiosurgery of arteriovenous malformations and acoustic neuromas.不同治疗方式在立体定向放射手术治疗动静脉畸形和听神经瘤中的剂量学比较。
Radiother Oncol. 2013 Feb;106(2):192-7. doi: 10.1016/j.radonc.2012.07.002. Epub 2012 Aug 10.
8
Factors associated with hearing preservation after Gamma Knife surgery for vestibular schwannomas in patients who retain serviceable hearing.保留有用听力的患者行伽玛刀治疗前庭神经鞘瘤后听力保留相关因素。
J Neurosurg. 2011 Dec;115(6):1078-86. doi: 10.3171/2011.7.JNS11749. Epub 2011 Aug 26.
9
Evaluation of hearing function after Gamma Knife surgery of vestibular schwannomas.前庭神经鞘瘤伽玛刀手术后听力功能评估。
Neurosurg Focus. 2009 Dec;27(6):E3. doi: 10.3171/2009.9.FOCUS09196.
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Sudden sensorineural hearing loss as a revealing symptom of vestibular schwannoma.突发性感音神经性听力损失作为前庭神经鞘瘤的首发症状
Acta Otolaryngol. 2005 Jun;125(6):592-5. doi: 10.1080/00016480510030246.