单发直肠神经内分泌肿瘤伴多发内分泌细胞微巢

Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests.

作者信息

Suzuki Sho, Kawakami Hiroshi, Miike Tadashi, Yamamoto Shojiro, Abe Hiroo, Shimoda Kazuya, Ashizuka Shinya, Inatsu Haruhiko, Kubota Yoshimasa, Ban Tesshin, Yorita Kenji, Kataoka Hiroaki

机构信息

Department of Gastroenterology and Hematology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Japan.

Department of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan.

出版信息

Intern Med. 2020 Mar 1;59(5):619-623. doi: 10.2169/internalmedicine.3582-19. Epub 2019 Oct 31.

DOI:10.2169/internalmedicine.3582-19

PMID:31666465

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7086335/

Abstract

Although a few reports of neuroendocrine tumor (NET) in the stomach or appendix with surrounding micronests have been published, cases of rectal NET are rare. We herein report a unique case of a patient with single rectal NET treated endoscopically. A pathological examination revealed multiple endocrine cell micronests (ECMs) in the submucosal layer around the main NET lesion. Neither lymph node metastasis nor distant metastasis in computed tomography was observed six years after the treatment. Because case reports of multiple ECM are very rare, the significance of malignancy is unclear. It therefore appears to be necessary to accumulate similar cases.

摘要

尽管已经发表了一些关于胃或阑尾神经内分泌肿瘤（NET）伴周围微巢的报道，但直肠NET病例罕见。我们在此报告一例经内镜治疗的单发直肠NET患者的独特病例。病理检查显示，在主要NET病变周围的黏膜下层有多个内分泌细胞微巢（ECM）。治疗六年之后，计算机断层扫描未发现淋巴结转移或远处转移。由于多个ECM的病例报告非常罕见，其恶性程度的意义尚不清楚。因此，积累类似病例似乎很有必要。