Pietzsch Stefan, Ricke-Hoch Melanie, Stapel Britta, Hilfiker-Kleiner Denise
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Data Brief. 2019 Sep 18;26:104508. doi: 10.1016/j.dib.2019.104508. eCollection 2019 Oct.
The dataset describes protein expression of phosphorylated and total signal transducer and activator of transcription 3 (STAT3), protein kinase B (AKT) and suppressor of cytokine signalling 3 (SOCS3) in left ventricular tissue (LV) from healthy and B16F10 melanoma tumour-bearing (B16F10-TM) wildtype (WT) mice, mice with cardiomyocyte-specific constitutively active AKT transgene (AKTtg) and mice with cardiomyocyte-restricted deletion of STAT3 (CKO) analysed in Western blot and/or fluorescence microscopy experiments. The data presented in this article are related to the research paper entitled "Modulation of cardiac AKT and STAT3 signalling in preclinical cancer models and their impact on the heart", available in Biochim. Biophys. Acta Mol. Cell Res. (1).
该数据集描述了在健康野生型（WT）小鼠、携带B16F10黑色素瘤肿瘤的（B16F10-TM）野生型小鼠、具有心肌细胞特异性组成型活性AKT转基因的小鼠（AKTtg）以及心肌细胞限制性缺失STAT3的小鼠（CKO）的左心室组织（LV）中，磷酸化和总信号转导子及转录激活子3（STAT3）、蛋白激酶B（AKT）和细胞因子信号转导抑制因子3（SOCS3）的蛋白质表达情况，这些是通过蛋白质印迹法和/或荧光显微镜实验进行分析的。本文所呈现的数据与发表在《生物化学与生物物理学报：分子细胞研究》（1）上的题为“临床前癌症模型中心脏AKT和STAT3信号传导的调节及其对心脏的影响”的研究论文相关。
